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Primary Epstein-Barr virus (EBV) infection occurs frequently in children and causes various clinical manifestations. The patients may be asymptomatic and spontaneously recover from infection or has severe symptoms with fatal complication. The frequent manifestations include fever, exudative pharyngotonsillitis, and lymphadenopathy. EBV infection leads to mild and selflimited increase in liver enzymes. However, clinical manifestations of hepatitis including jaundice are very rare in children, with only several cases previously reported in the medical literature.
We report a case of an 11 years 8 months old girl who was hospitalized because of cholestatic hepatitis induced by EBV infection.
EBV infection should be considered in the differential diagnosis of cholestatic hepatitis in children, in order to avoid unnecessary investigations.
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