Treatment Outcomes after Breast Conserving Therapy in Breast Cancer Patients in Faculty of Medicine, Vajira Hospital: a 10-Year Retrospective Study

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Published: Apr 29, 2022
DOI: https://doi.org/10.14456/vmj.2022.10
Keywords:
breast cancer BCT long term out come

Main Article Content

Kanisa Rongsriyam
Department of Radiology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand
Kamonrat Sueangamiam
Department of Radiological Technology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand
https://orcid.org/0000-0002-2700-3098
Thanatip Tantivatana
Department of Radiology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand

Abstract

Objective: To study the 5 and 10-year survival rate and prognosis factors in breast cancer patients receiving breast conservative treatment (BCT).


Methods: A retrospective descriptive analysis of BCT patients who were treated in Radiation Oncology unit, Department of Radiology, Faculty of Medicine Vajira Hospital between 2009 and 2019. The Kaplan-Meier method was used for survival analysis. The authors analyzed association of patients and tumor characteristics with survival using the log-rank test and Cox models.


Results: A total of 158 BCT patients were included. Five-year overall and disease-free survivals were 100% and 97.8%, respectively, with 10-year overall survival and disease-free survival were 100% and 95.7%, respectively. Numbers of positive nodes more than 4 (HR of 10.25; 95% CI:1.66-63.18) are significantly prognostic factors related to recurrence.


Conclusions: Breast cancer patients who were treated with BCT had a favorable long-term survival outcome. Survival rates did not change much between 5 and 10 years. The important prognostic factor affecting disease-free survival was axillary lymph node metastasis.

Article Details

How to Cite
Rongsriyam, K., Sueangamiam, K., & Tantivatana, T. (2022). Treatment Outcomes after Breast Conserving Therapy in Breast Cancer Patients in Faculty of Medicine, Vajira Hospital: a 10-Year Retrospective Study. Vajira Medical Journal : Journal of Urban Medicine, 66(2), 95–102. https://doi.org/10.14456/vmj.2022.10
Issue
Vol. 66 No. 2 (2022): Mar - Apr 2022
Section
Original Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Author Biography

Kamonrat Sueangamiam, Department of Radiological Technology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand

NAME                                      Kamonrat   Sueangamiam

DATE OF BIRT                       October 21, 1977

CONTACT                                Department of radiological Technology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok

                                                   Tel.084-6678201, Emai; kamonrat@nmu.ac.th

EDUCATION

2002-2004                             Bachelor of Science, ( Radiological Technology),            

                                               Faculty of Science, Ramkhamhaeng University, Bangkok

2013-2515                             Master of Science, (Medical Imaging) Faculty of Medicine,
                                               Chulalongkorn University,Bangkok

SCHOLARSHIP

2014-2015                              Teacher assistant, Faculty of Medicine, Department of Radiology, Chulalongkorn University, Bangkok

PUBLICATION

  1. Sueangamiam K, Suriyapee S, Sanghangthum T. Planning target volume margin determination in VMAT prostate region using CBCT. Journal of Thai Association of Radiation Oncology. 2017; l23:27-37
  2. Tantivatana T. Rongsriyam K, Chongthanakorn M, Sueangamiam K. Long-term outcomes after concurrent chemoradiotherapy in cervical cancer: Journal of the Medical Association of  Thailand 2018; 101(Suppl 8):S131-36

References

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136(5):359–86.

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68(6):394-424.

Virani S, Bilheem S, Chansaard W, Chitapanarux I, Daoprasert K, Khuanchana S, et al. Nationaland subnational population-based incidence of cancer in Thailand: assessing cancers with the highest burdens. Cancers 2017;9(8):180. doi: 10.3390/cancers9080108.

Goldhirsch A, Wood WC, Gelber RD, Coates AS, Thürlimann B, Senn HJ. Meeting highlights: updated international expert consensus on the primary therapy of early breast cancer. J Clin Oncol 2003;21(17):3357-65.

Colleoni M, Gelber S, Coates AS, CastiglioneGertsch M, Gelber RD, Price K, et al. Influence of endocrine-related factors on response to perioperative chemotherapy for patients with node-negative breast cancer. J Clin Oncol 2001;19(21):4141-9.

Hayes DF. Markers of increased risk for failure of adjuvant therapies. Breast 2003;12(6):543-9.

Allred DC, Harvey JM, Berardo M, Clark GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol 1998 ;11(2):155-68.

Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002;347(16):1233-41.

Darby S, McGale P, Correa C, Taylor C, Arriagada R, Clarke M, et al. Effect of radiotherapy after breastconserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet 2011;378(9804):1707-16.

Arriagada R, Lê MG, Rochard F, Contesso G. Conservative treatment versus mastectomy in early breast cancer: patterns of failure with 15 years of follow-up data. Institut Gustave-Roussy Breast Cancer Group. J Clin Oncol 1996;14(5):1558-64.

Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, et al. Twenty-year follow-up of a randomized study comparing breastconserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002;347(16):1227–32.

Voogd AC, Nielsen M, Peterse JL, Blichert-Toft M, Bartelink H, Overgaard M, et al. Differences in risk factors for local and distant recurrence after breast-conserving therapy or mastectomy for stage I and II breast cancer: pooled results of two large European randomized trials. J Clin Oncol 2001;19(6):1688–97.

Poggi MM, Danforth DN, Sciuto LC, Smith SL, Steinberg SM, Liewehr DJ, et al. Eighteen-year results in the treatment of early breast carcinoma with mastectomy versus breast conservation therapy: The National Cancer Institute Randomized Trial. Cancers 2003;98(4):697–702.

Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 2010;17(6): 1471–74.

van Dongen JA, Voogd AC, Fentiman IS, Legrand C, Sylvester RJ, Tong D, et al. Long-term results of a randomized trial comparing breastconserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst 2000;92(14):1143-50.

Lagendijk M, van Maaren MC, Saadatmand S, Strobbe LJA, Poortmans PMP, Koppert LB, et al. Breast conserving therapy and mastectomy revisited: Breast cancer-specific survival and the influence of prognostic factors in 129,692 patients. Int J Cancer 2018;142:165-75.

Johns N, Dixon JM. Should patients with early breast cancer still be offered the choice of breast conserving surgery or mastectomy? Eur J Surg Oncol 2016;42(11):1636-41.

Tantivatana T, Chongthanakorn M, Rongsriyam K, Katanyoo K. Treatment outcomes and prognostic factors of patients with breast cancer: a retrospective review. J Med Assoc Thai 2009;92(8):1084-93.

Stotter AT, McNeese MD, Ames FC, Oswald MJ, Ellerbroek NA. Predicting the rate and extent of locoregional failure after breast conservation therapy for early breast cancer. Cancer 1989;64(11):2217-25.

Kurtz JM, Spitalier JM, Amalric R, Brandone H, Ayme Y, Bressac C, et al. Mammary recurrences in women younger than forty. Int J Radiat Oncol Biol Phys 1988;15(2):271-6.

Recht A, Connolly JL, Schnitt SJ, Silver B, Rose MA, Love S, et al. The effect of young age on tumor recurrence in the treated breast after conservative surgery and radiotherapy. Int J Radiat Oncol Biol Phys 1988;14:3-10.

Calle R, Vilcoq JR, Zafrani B, Vielh P, Fourquet A. Local control and survival of breast cancer treated by limited surgery followed by irradiation. Int J Radiat Oncol Biol Phys 1986;12(6):873-8.

Borger J, Kemperman H, Hart A, Peterse H, van Dongen J, Bartelink H. Risk factors in breastconservation therapy. J Clin Oncol 1994;12(4):653-60.

Mate TP, Carter D, Fischer DB, Hartman PV, McKhann C, Merino M, et al. A clinical and histopathologic analysis of the results of conservation surgery and radiation therapy in stage I and II breast carcinoma. Cancer 1986;58(9):1995-2002.

Solin LJ, Fowble B, Schultz DJ, Goodman RL. Age as a prognostic factor for patients treated with definitive irradiation for early stage breast cancer. Int J Radiat Oncol Biol Phys 1989;16(2):373-81.

Anscher MS, Jones P, Prosnitz LR, Blackstock W, Hebert M, Reddick R, et al. Local failure and margin status in early-stage breast carcinoma treated with conservation surgery and radiation therapy. Ann Surg 1993;218:22-8.

Spivak B, Khanna MM, Tafra L, Juillard G, Giuliano AE. Margin status and local recurrence after breastconserving surgery. Arch Surg 1994;129(9): 952-7.

Smitt MC, Nowels KW, Zdeblick MJ, Jeffrey S, Carlson RW, Stockdale FE, et al. The importance of the lumpectomy surgical margin status in long term results of breast conservation. Cancer 1995;76(2):259-67.