Pediatric Chikungunya Infection: Rheumatology Perspectives

Main Article Content

Sirikarn Tangcheewinsirikul

Abstract

Chikungunya infection (CI) is caused by the chikungunya virus, which is spread by Aedes mosquitos. CI has been reported in both pediatric and adult patients with a range of clinical phenotypes, notably musculoskeletal (MSK) symptoms. In young children, particularly in the newborn age, the symptoms are frequently severe. Thailand, which is located in the tropical tropics, has had several outbreaks of CI. As a result, pediatricians and general practitioners should be aware of the disease’s natural course as well as management guidelines. This article aims to inform pediatricians and general practitioners on the clinical characteristics particularly MSK complaints, diagnostic criteria, differential diagnosis, laboratory investigations and treatment guidelines for pediatric patients with chikungunya infection from rheumatology’s point of view.

Article Details

How to Cite
Tangcheewinsirikul, S. (2021). Pediatric Chikungunya Infection: Rheumatology Perspectives. Vajira Medical Journal : Journal of Urban Medicine, 65(Supplement November), S117–124. https://doi.org/10.14456/vmj.2021.57
Section
Review Articles

References

Ritz N, Hufnagel M, Gerardin P. Chikungunya in Children. Pediatr Infect Dis J 2015;34(7):789-91.

Gerardin P, Couderc T, Bintner M, Tournebize P, Renouil M, Lemant J, et al. Chikungunya virusassociated encephalitis: A cohort study on La Reunion Island, 2005-2009. Neurology. 2016;86:94-102.

Pham PN, Williams LT, Obot U, Padilla LA, Aung M, Akinyemiju TF, et al. Epidemiology of Chikungunya fever outbreak in Western Jamaica during July-December 2014. Res Rep Trop Med 2017;8:7-16.

Mason PJ, Haddow AJ. An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53; an additional note on Chikungunya virus isolations and serum antibodies. Trans R Soc Trop Med Hyg 1957;51(3):238-40.

Dupuis-Maguiraga L, Noret M, Brun S, Le Grand R, Gras G, Roques P. Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia. PLoS Negl Trop Dis 2012;6(3):e1446. doi: 10.1371/journal.pntd.0001446.

Gasque P, Bandjee MC, Reyes MM, Viasus D. Chikungunya Pathogenesis: From the Clinics to the Bench. J Infect Dis 2016;214 Suppl 5: S446-S8. doi: 10.1093/infdis/jiw362.

Vairo F, Haider N, Kock R, Ntoumi F, Ippolito G, Zumla A. Chikungunya: Epidemiology, Pathogenesis, Clinical Features, Management, and Prevention. Infect Dis Clin North Am 2019;33(4):1003-25.

Ryman KD, Klimstra WB. Host responses to alphavirus infection. Immunol Rev 2008;225:27-45.

Carpentier KS, Morrison TE. Innate immune control of alphavirus infection. Curr Opin Virol 2018;28:53-60.

Marr N, Wang TI, Kam SH, Hu YS, Sharma AA, Lam A, et al. Attenuation of respiratory syncytial virus-induced and RIG-I-dependent type I IFN responses in human neonates and very young children. J Immunol 2014;192(3):948-57.

Prow NA, Tang B, Gardner J, Le TT, Taylor A, Poo YS, et al. Lower temperatures reduce type I interferon activity and promote alphaviral arthritis. PLoS Pathog 2017;13(12):e1006788. doi: 10.1371/journal.ppat.1006788.

Hoarau JJ, Jaffar Bandjee MC, Krejbich Trotot P, Das T, Li-Pat-Yuen G, Dassa B, et al. Persistent chronic inflammation and infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune response. J Immunol 2010;184(10):5914-27.

Brouard C, Bernillon P, Quatresous I, Pillonel J, Assal A, De Valk H, et al. Estimated risk of Chikungunya viremic blood donation during an epidemic on Reunion Island in the Indian Ocean, 2005 to 2007. Transfusion 2008;48(7):1333-41.

Appassakij H, Khuntikij P, Kemapunmanus M, Wutthanarungsan R, Silpapojakul K. Viremic profiles in asymptomatic and symptomatic chikungunya fever: a blood transfusion threat? Transfusion 2013;53:2567-74.

Simon F, Javelle E, Cabie A, Bouquillard E, Troisgros O, Gentile G, et al. French guidelines for the management of chikungunya (acute and persistent presentations). November 2014. Med Mal Infect 2015;45(7):243-63.

Zaid A, Gerardin P, Taylor A, Mostafavi H, Malvy D, Mahalingam S. Chikungunya Arthritis: Implications of Acute and Chronic Inflammation Mechanisms on Disease Management. Arthritis Rheumatol 2018;70(4):484-95.

Suhrbier A. Rheumatic manifestations of chikungunya: emerging concepts and interventions. Nat Rev Rheumatol 2019;15(10):597-611.

Sharma SK, Jain S. Chikungunya: A rheumatologist's perspective. Int J Rheum Dis 2018;21(3):584-601.

Kumar A, Best C, Benskin G. Epidemiology, Clinical and Laboratory Features and Course of Chikungunya among a Cohort of Children during the First Caribbean Epidemic. J Trop Pediatr 2017;63:43-9.

Beserra F, Oliveira GM, Marques TMA, Farias L, Santos JRD, Daher EF, et al. Clinical and laboratory profiles of children with severe chikungunya infection. Rev Soc Bras Med Trop 2019;52:e20180232. doi: 10.1590/0037-8682-0232-2018.

European Centre for Disease Prevention and Control. Factsheet about Chikungunya [Internet]. 2021 [cited 2021 Jun 1]. Available from: https://www.ecdc.europa.eu/en/chikungunya/facts/factsheet.

World Health Organization. Guidelines on Clinical Management of Chikungunya Fever [Internet]. 2019 Dec [cited 2021 Jun 1]. Available from: https://www.who.int/publications/i/item/guidelines-on-clinical-management-ofchikungunya-fever.

Chikungunya: case definitions for acute, atypical and chronic cases. Conclusions of an expert consultation, Managua, Nicaragua, 20-21 May 2015. Wkly Epidemiol Rec 2015;90(33):410-4.

van Keulen V, Huibers M, Manshande M, van Hensbroek MB, van Rooij L. Chikungunya Virus Infections Among Infants-Who Classification Not Applicable. Pediatr Infect Dis J 2018;37(3):e83-e6. doi: 10.1097/INF.0000000000001826.

Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 2004;31(2):390-2.

Suhrbier A, Jaffar-Bandjee MC, Gasque P. Arthritogenic alphaviruses--an overview. Nat Rev Rheumatol 2012;8(7):420-9.

Weaver SC, Lecuit M. Chikungunya virus and the global spread of a mosquito-borne disease. N Engl J Med 2015;372(13):1231-9.

World Health Organization. Guidelines for Prevention and Control of Chikungunya Fever [Internet]. 2009 [cited 2021 Jun 1]. Available from: http://apps.who.int/iris/bitstream/handle/10665/205166/B4289.pdf.

Ryan S. Funk SB, Jennifer C. Cooper,Mara L. Becker. Therapeutics: Nonbiologics. In: Ross E. Petty RML, Carol B. Lindsley,Lucy R. Wadderburn, Elizabeth D. Mellins,Robert C. Fuhlbrigge, editor. Textbook of Pediatric Rheumatology. 8 ed. Philadelphia: Elsevier; 2021.

Centers for Disease Control and Prevention. Chikungunya Virus [Internet]. 2018 [cited 2021 Jun 1]. Available from: https://www.cdc.gov/chikungunya/symptoms/index.html.

Burt FJ, Rolph MS, Rulli NE, Mahalingam S, Heise MT. Chikungunya: a re-emerging virus. Lancet 2012;379(9816):662-71.

Chang AY, Encinales L, Porras A, Pacheco N, Reid SP, Martins KAO, et al. Frequency of Chronic Joint Pain Following Chikungunya Virus Infection: A Colombian Cohort Study. Arthritis Rheumatol 2018;70(4):578-84.

Lemant J, Boisson V, Winer A, Thibault L, Andre H, Tixier F, et al. Serious acute chikungunya virus infection requiring intensive care during the Reunion Island outbreak in 2005-2006. Crit Care Med 2008;36(9):2536-41.