A 5-Year-Retrospective Review: The Clinical Outcome between Adequate and Inadequate of Initial Antibiotics Treatment in Pediatric Patients, Vajira Hospital The Outcome between Adequate and Inadequate Empirical Antibiotics
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Abstract
OBJECTIVE: The results of adequate and inadequate empirical antibiotics remain unclear. This study aimed to evaluate the results of using adequate and inadequate empirical antibiotics.
METHODS: A retrospective cohort analysis that covered January 2017 and December 2021 was conducted. At Vajira Hospital, we enlisted pediatric patients with bacteremia and urinary tract infections (UTIs). Patient attributes, empirical antibiotics, therapeutic results, financial expenditures, and antibiotic susceptibility patterns were assessed.
RESULTS: In total, 286 pediatric patients were enrolled. There were 230 (80.4%), and 56 (19.6%) patients with UTIs and bacteremia, respectively. The organism that was found the most frequently was Escherichia coli (53.5%), while third-generation cephalosporin was the most often used empirical antibiotic (74.5%). Only 78.4% of Escherichia coli were vulnerable to third-generation cephalosporin.
Of 220 patients (76.9%) were treated with adequate empirical antibiotics. The outcomes in the adequate empirical antibiotics group revealed better-improved symptoms than inadequate empirical antibiotics group (96.4% VS 84.8%, p = 0.002).
CONCLUSION: Clinical outcomes among pediatric patients from adequate initial antibiotics groups were reported the better outcomes. The mortality rates were not different. Nonetheless, appropriate empirical antibiotics are needed. In UTI patients, amikacin is preferable options for empirical antibiotics.
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