A Randomized Comparison of Oral Sodium phosphate within 30 and 75 Minutes In Bowel Preparation for Colonoscopy

Abstract

A Randomized Comparison of Oral Sodium phosphate within 30 and 75 Minutes In Bowel Preparation for Colonoscopy

Tassanee                Sirirutamaprapan       BN, BHEcon*

Chanpreecha         Chamtrachamnong    MD**

Somboon                Charoenthamaha       MD**

Prayuth                  Sirivongs                       MD**

Nipa                         Orprasert                      BN*

Boonchai                Ngamsirimas                MD**

* Nursing Department, BMA Medical College and Vajira Hospital

** Department of Surgery, BMA Medical College and Vajira Hospital

Objective: To compare the side effects (nausea and vomiting) and large bowel cleanness of 90 ml oral sodium phosphate within 30 minutes and 75 minutes for large bowel preparation before colonoscopy.

Study design: Prospective, randomized controlled study.

Subjects: Two hundred and thirteen patients who underwent elective colonoscopy from various indications at Endoscopic Surgery Division, Department of Surgery, BMA Medical College and Vajira Hospital during January 2005 to July 2005, were enrolled in this study.

Methods: The subjects were allocated into 2 groups. The first, 99 cases drank 90 ml of sodium phosphate for large bowel preparation within 30 minutes as controls. The second, 114 cases drank the same amount within 75 minutes as study group, Research assistants interviewed all subjects to evaluate nausea and vomiting after taking this laxative, The surgeons performing colonoscopy did not know about the administration techniques and assessed the cleanness of large bowel by using the scores that prepared before the study.

Main outcome measures: Incidence of nausea and vomiting, large bowel cleanness score.

Results: Nausea occurred in 71.7% of the patients in 30 minutes group which was higher significantly than 45.6% in the 75 minutes group (p-value < 0.001). In addition, vomiting occurred in 45.4% and 27.2% in the 30 minutes group and 75 minutes group respectively (p-value < 0.05). The cleanness score of large            bowel were not different with the same mean score of 3.4.

Conclusion: Large bowel preparation by taking sodium phosphate orally within 75 minutes had less side effects                than the                 30 minutes group. Furthermore, the cleanness of the large bowel was not different between two techniques.

Key words: bowel preparation, oral sodium phosphate, colonoscopy, nausea, vomiting