A Review of the Beneficial Effects of Hesperidin on Urban Diseases Urban Diseases and the Potential of Hesperidin
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Abstract
The urban environment is increasingly recognized as a key determinant of health, influencing lifestyles that can either promote or hinder well-being. This review aims to summarize recent studies (2020-2024) on the potential therapeutic effects of hesperidin, a flavonoid derived from citrus fruits, in addressing urban-related diseases worsened by pollution, sedentary habits, poor nutrition, and chronic stress. These health conditions include cardiovascular diseases respiratory issues, metabolic disorders, neurodegenerative diseases, mental health challenges, infectious diseases, and cancer. Hesperidin’s anti-inflammatory, antioxidant, and immunomodulatory properties have shown promise in improving cardiovascular health, reducing oxidative stress, enhancing insulin sensitivity, protecting against neurodegeneration, alleviating mental health symptoms, reducing respiratory inflammation, and inhibiting cancer cell growth. While preclinical studies show encouraging results, clinical evidence remains limited, underscoring the need for further research to validate its safety, efficacy, and optimal dosage for urban health interventions.
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