Acquired Hemophilia A (Factor VIII inhibitor) associated with Bullous Pemphigoid: A Case Report

Abstract

Acquired Hemophilia A (Factor VIII inhibitor) associated with Bullous Pemphigoid: A Case Report

Wiwat Rodprasert MD

Rachanid Pornvipavee MD

Department of Medicine, BMA Medical College and Vajira Hospital

Acquired hemophilia A or factor VIII inhibitor is an autoimmune disease resulting from the presence of autoantibody to factor VIII. The prevalence is less than hereditary forms. It can be found in all races and ages but it is more common in middle age and older. Male and female are equally affected. It can be found alone or associated with other autoimmune diseases, malignancy, some medications and pregnancy. This is a case of Thai male patient presenting with bullous pemphigoid and ecchymosis. The diagnasis is acquired hemophilia A. Its managements consist of investigation and treatment the associated diseases, immunosuppressive agents and control bleeding disorder.

Vajira Med J 2007 ; 51 : 55 - 59