Pregnant Women Undergoing Prenatal Diagnosis for Thalassemia in BMA Medical College and Vajira Hospital: Case Series

Abstract

Pregnant Women Undergoing Prenatal Diagnosis for Thalassemia in BMA Medical College and Vajira Hospital: Case Series

Chadakarn Phaloprakarn MD

Department of Obstetrics and Gynecology, BMA Medical College and Vajira Hospital

In this case series, data on pregnant women who underwent invasive prenatal diagnosis for thalassemia at the Department of Obstetrics and Gynecology, BMA Medical College and Vajira Hospital between January 2006 and December 2007 were reported. During the 2-year period, there were six amniocentesis for fetal DNA study and eight cordocentesis for hemoglobin (Hb) typing. None of the procedure-related complications was observed. Five fetuses were diagnosed as Hb Bart's hydrops fetalis; 3 were terminated while the other 2 cases were lost to follow-up. Two fetuses who were diagnosed as b-thalassemia/Hb E disease were also terminated. The remaining 7 fetuses were identified as thalassemia trait or normal condition. Standard antenatal care was applied to these fetuses until delivery.

Vajira Med J 2008 ; 52 : 167 - 174