Prevalence and Association between Androgen Deficiency and Metabolic Syndrome in Aging Thai Male with Type 2 Diabetes Mellitus

Abstract

Prevalence and Association between Androgen Deficiency and Metabolic Syndrome in Aging Thai Male with Type 2 Diabetes Mellitus

Swangjit     Sura-amornkul               MD, FRCP (T),MSc (Chinical Investigation)

Thantip       Jongboonyanupap         MD, FRCP (T)

Petch          Rawdaree                         MD, FRCP (T),MSc

Endocrinology unit, Department of Medicine, BMA Medical College and Vajira Hospital.

Objective: To determine the prevalence and association between androgen deficiency (AD) and metabolic syndrome in aging Thai male with type 2 diabetes mellitus.

Study design: Cross-sectional study.

Subjects: 246 males aged ≥ 55 years old with type 2 diabetes who attended Diabetic Clinic, Department of Medicine, BMA Medical College and Vajira Hospital from June 2007 to October 2008.

Methods: Waist circumference and blood pressure were measured. Blood was drawn for fasting plasma glucose, glycated hemoglobin (),lipid and total testosterone levels in all participants.

Main outcome measures: total testosterone level, metabolic syndrome according to American Heart Association (AHA) criteria.

Results: Prevalence of androgen deficiency (AD) in aging Thai male with type 2 diabetes was 35.8%. The total testosterone level of type 2 diabetes aging male with and without AD was 2.55 ± 0.74 and 4.95 ± 1.44 ng/ml respectively. Body weight, body mass index (BMI) and waist circumference were significantly negatively correlated with total testosterone levels. Prevalence of metabolic syndrome in type 2 diabetes aging male with and without AD was not significantly different (87.5% vs 83.5%).

Conclusion: AD was frequently found in aging Thai male with type 2 diabetes. However, there was no association between AD and metabolic syndrome in this group.

Vajira Med J 2009 ; 53 : 33 - 39