Use of Intravenous Immunoglobulin (IVIg)

Abstract

Use of Intravenous Immunoglobulin (IVIg)

Panadda Suwan MD

Department of Pediatrics, BMA Medical College and Vajira Hospital

Initially used as a replacement therapy for immunodeficiency diseases, intravenous immunoglobulin (IVIg) is now widely used for a number of autoimmune and inflammatory diseases. The mechanisms of action of IVIg are several, it can modulate an immune reaction at the level of T cells, B cells, macrophages, the complement cascade and the cytokine network. Given the potential risks and cost-effectiveness of IVIg, careful consideration of the indications and administration of IVIg is warranted.

Vajira Med J 2009 ; 53 : 89 - 100