Results of Testosterone Replacement Therapy in Ag ing Male

Abstract

Results of Testosterone Replacement Therapy in Aging Male

Phatr Sae Tang

Department of Surgery, BMA Medical College and Vajira Hospital.

Objective: To study the effects of testosterone undecanoate in late onset hypogonadal men.

Study design: Retrospective descriptive study.

Subjects: A total of 50 late onset hypogonadal men aged of 40 years or more who were treated with testosterone undecanoate either in oral form (Andriol Testocaps) or intramuscular injection form (Nebido) at men's health clinic in BMA Medical College and Vajira Hospital during July 2006 and October 2007

Methods: Data of all late onset hypogonadal patients during the study period were retrospectively reviewd from the medical records. Data from the answers of The St. Louis University Questionnaire for Androgen deficiency in Aging Male (ADAM) together with pretreatment total testosterones and PSA (prostate specific antigen) level and 34 weeks post treatment level were also collected.

Main outcome measures: Results of ADAM questionnaire and total testosterone level.

Results: The mean age of the subjects were 61.1 ± 10.0 years. The proportion of the subjects who had problems in sexual dysfunction, muscle mass strength and physical function, mood and cognition decreased significantly from 74-96% to 0-4% after treatment. The mean total testosterone level increased significantly from 2.77 ± 1.08 to 6.27 ± 2.76 ng/ml, while the mean PSA level was not significantly changed (1.15 ± 0.86 vs 1.35 ± 0.99 ng/ml). There was no adverse effect in any of the patients.

Conclusion: Treatement of late onset hypogonadal men with testosterone undecanoate yielded good results and safe.

Vajira Med J 2009 ; 53 : 243-251