Bedtime Dosing of Antihypertensive Drugs in Chronic Kidney Disease Patients with Hypertension

Abstract

Chronic kidney disease patients with hypertension whose blood pressure remained above goal resulted in subsequent deterioration in renal function and was at high risk of cardiovascular diseases. These remarkably impacted on patients with non-dipping blood pressure pattern. Accordingly, many studies revealed that nocturnal ambulatory blood pressure, the prevalence of non-dipper pattern, decline in estimated glomerular filtration rate and risk of cardiovascular events
were reduced by taking at least one antihypertensive drug at bedtime rather than in the morning in chronic kidney disease patients with hypertension, especially with the non-dipping blood pressure pattern.