Effectiveness and Safety of Thunbergia laurifolia Herbal Tea in Alcohol Withdrawal Syndrome in Sangkha Hospital, Surin
Keywords:
thunbergia laurifolia, herb, alcohol drinking, withdrawal, complicationAbstract
Objective: To study the effectiveness and safety of using T. laurifolia herbal tea in patients with Alcohol Withdrawal Syndrome (AWS) at Sangkha Hospital, Surin. Method: A prospective and retrospective study comparing patients diagnosed with AWS that were treated with symptom-trigger regimen for AWS protocol during 2022-2023. Result: The study found that in the experimental group with a lower average AWS score compared to the control group on the 4th and 5th days after symptom onset, there was a lower use of benzodiazepines and haloperidol for symptom control. Additionally, the experimental group had a shorter hospital stay and a lower incidence of pneumonia acquired through aspiration compared to the control group. No abnormal symptoms or side effects were observed from using the tapering schedule during the hospital stay. Furthermore, it was found that patients with chronic alcoholism were associated with refeeding syndrome, and the tapering schedule was also effective in treating alcoholic hepatitis. Conclusion: The use of T. laurifolia herbal tea can be a suitable additional treatment option to help alleviate symptoms of AWS, providing benefits in terms of reducing hospital stay and potential complications. However, there is insufficient data to conclude whether the T. laurifolia herbal tea alone can effectively reduce the severity of symptoms caused by alcohol deprivation.
References
Nutt DJ, Glue P. Neuropharmacological and clinical aspects of alcohol withdrawal. Ann Med 1990; 22: 275-281.
Bharadwaj B, Kattimani S. Clinical management of alcohol withdrawal: A systematic review. Industrial Psychiatry Journal. 2013; 22(2): 100.
Saitz R. Introduction to Alcohol Withdrawal. Alcohol Health and Research World.1998; 22(1): 5–12.
Rinaldi RC, Steindler EM, Wilford BB. Clarification and standardization of substance abuse terminology. JAMA 1988; 259: 555-557.
Jellinek EM et al. The “Craving” for Alcohol; A Symposium by Members of the WHO Expert Committees on Mental Health and on Alcohol. Quarterly Journal of Studies on Alcohol. 1955 Mar 1;16(1):34–66.
Reed JS, Liskow BI. Current medical treatment of alcohol withdrawal. Rational Drug Therapy 1987; 21: 1-6.
Anton RF, et al. Efficacy of gabapentin for the treatment of alcohol use disorder in patients with alcohol withdrawal symptoms: A randomized clinical trial. JAMA Internal Medicine. 2020; 180(5): 728–36.
Niyomthong C. Associated Factors in Predicting Alcohol Withdrawal Severity. Med J Sisaket Surin Buriram Hosp. 2020 Dec. 30;35(3):595-604.
28. Frances RJ, et al. Textbook of Neuropsychiatry. Washington, DC: American Psychiatric Press, 1992: 563-584.
Whitfield CL, Thomson G, Lamb A, Spencer V, Pfeifer M, Browning-Ferrando M. Detoxification of 1024 alcoholic patients without psychoactive drugs. JAMA 1978; 239: 1409-1410.
Naranjo CA, Sellers EM, Chator K. Nonpharmacological intervention in acute alcohol withdrawal.Clin Pharmacol Ther 1983; 34:214-219
Shaw JM, Kolesar GS, Sellers EM. Development of optimal treatment tactics for alcohol withdrawal. J Clin Psychopharmacol 1981;1: 381-389.
Rosenbloom A. Emerging treatment options in the alcohol withdrawal syndrome. J Clin Psychiatry 1988; 49:12 suppl: 28-31.
Liskow BI, Goodwin DW. Pharmacological treatment of alcohol intoxication, withdrawal, and dependence: A critical review. J Stud Alc 1987. 48:356-370.
Anchalee Chuthaputti. Laurel Clock Vine (Thunbergia laurifolia Lindl.): A Detoxifying Herb. Journal of Thai Traditional and Alternative Medicine 2010; 8: 2-3: 211-220.
Maneesen C. The Study of Thunbergia laurifolia Lindl. (Rang Jued) Usage as Antidote. 2020 Mar.;3(1):28-40.
Arpaporn Piwondee. Effect of rang chuet extract on glutathione s-transferase in rat livers and thermal stability of its phytochemicals. Sutacth [Internet]. 2013 [cited 2022 Oct 11]; Available from: http://sutir.sut.ac.th:8080/jspui/handle/123456789/5183.
Wirote Lertpongpipa. Comparison of Effectiveness on Increasing Cholinesterase Blood Level between Thunbergiaceae and Bauhinia strychnifolia Craib in Agriculturists. 2019 Jan. 15;18(3):49-58.
Puangchaibodin P, Saksiri N. The Efficiency of Thunberg laurifolia Lindl. and Bauhinia strychnifolia Craib. on Reduction of Blood Alcohol Concentration. RMUTTO Research Journal [Internet]. 2020 [cited 2023 Nov 29];13(1):120–8. Available from: https://li01.tci-thaijo.org/index.php/researchjournal2rmutto/article/view/244751.
Kaewkiriya K. Effects of drinking the water extracted of Thunbergia laurifolia linm. To reduce the amount of alcohol in breath [Internet]. Nu.ac.th. [cited 2022 Nov 29]. Available from: http://www.socsci.nu.ac.th/socant2017/downloads/proceeding/031.pdf.
Lerner, W. D., & Fallon, H. J. (1985). The alcohol withdrawal syndrome. The New England Journal of Medicine, 313(15), 951–952.
Elisaf M, Liberopoulos E, Bairaktari E, Siamopoulos K. Hypokalaemia in alcoholic patients. Drug Alcohol Rev. 2002;21(1):73–6.
Lin Y-Y, Hsieh Y-S. Chronic alcohol abuse-induced hypokalemia might lead to delayed diagnosis or misdiagnosis of thyrotoxic periodic paralysis. Cureus. 2021;13(6):e15880.
Elisaf MS, Siamopoulos KC. Mechanisms of hypophosphatemia in alcoholic patients. Int J Clin Pract. 1997;51(8):501–3.
Baj J, Flieger W, Teresinski G, Buszewicz G, Sitarz R, Forma A, et al. Magnesium, calcium, potassium, sodium, phosphorus, selenium, zinc, and chromium levels in alcohol use disorder: A review. J Clin Med. 2020;9(6):1901.
Parker R, McCune CA. Diagnosis and treatment of alcoholic hepatitis. Frontline Gastroenterology 2014; 5: 123-129.
Thursz M, Morgan TR. Treatment of severe alcoholic hepatitis. Gastroenterology 2016; 150(8):1823–34.
ดวงรัตน์ เชี่ยวชาญวิทย์.การใช้สมุนไพรรางจืดเพิ่มปริมาณเอนไซม์โคลีนเอสเทอเรสในซีรั่มของเกษตรกรที่พบสารกำจัดศัตรูพืชในร่างกาย.พุทธชินราชเวชสาร2545; 19: 12-20.
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