Comparison of ventilator-day in early sedation and non-sedation mechanically ventilated patients in ICU, Sangkha Hospital
Keywords:
Early Sedation, Mechanical ventilator, Duration of mechanical ventilation, Intensive care unit (ICU)Abstract
Sangkha Hospital in Surin Province is a community hospital with an increasing number of critically ill patients requiring mechanical ventilation. Sedation is a key practice for patients on ventilators, but there is limited evidence on the outcomes of early sedation (within 8 hours after intubation) compared to no sedation or delayed sedation. This study Aimed to compare the duration of mechanical ventilation, ICU length of stay, and mortality rates between patients who received early sedation and those who did not receive sedation or received it after 8 hours. The study design was a retrospective cohort, including patients aged 18 years or older who were intubated and mechanically ventilated in the ICU Sangkha Hospital. Patients were divided into two groups: those who received sedation within 8 hours after intubation and those who did not receive sedation or received it after 8 hours.
Among 187 patients, the early sedation group (n=98) required mechanical ventilation for a mean of 61.66 hours and stayed in the ICU for 111.27 hours, compared to 53.14 hours and 99.48 hours, respectively, in the non-early sedation group (n=89). However, the study found no statistically significant differences in mechanical ventilation duration, ICU length of stay, or mortality rates. But, there was a trend suggesting that early sedation might prolong mechanical ventilation and ICU stay. This study had limitations, including sample size and low disease severity, so further research—particularly randomized controlled trials—is needed to confirm these findings and assess other factors that may influence treatment outcomes.
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