Effect of intravenous fluid infusion in postoperative and post discharge nausea and vomiting (PONV/PDNV) in outpatient surgery, Ramathibodi Hospital

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Koravee Pasutharnchat


Introduction: Postoperative nausea and vomiting
is the most common complication after surgery.
A previous study showed that dehydration might be a
precipitating factor of postoperative nausea and
vomiting. Objectives: This study aimed to determine
the effect of perioperative intravenous fluid on
postoperative nausea and vomiting (PONV) and post-
discharge nausea and vomiting (PDNV) in ambulatory
surgical patients. Methods: A prospective cohort
study was conducted in 200 patients who were in
ASA 1-3, aged 18 years or older, and undergoing an
ambulatory surgery in Ramathibodi Hospital between
May 2014 to May 2015. Demographic data were
recorded. Amount of preoperative and intraoperative
intravenous fluid were reviewed. At PACU, the
incidents of PONV, thirst, dizziness at 30 minutes,
60 minutes and discharge time as well as patient
satisfaction score were evaluated. The incidence of
PDNV was collected by phone. Results: Two hundred
patients undergoing various ambulatory surgeries
were enrolled. The amount of perioperative IV fluid
administered was 8.06±5.17 ml/kg. Operative time
was 51.43±28.15 min. The incidents of PONV, thirst
and dizziness at 30 minutes after the procedures
were 8.5%, 50% and 25.5% respectively. No patient
was reported PDNV. Amount of intravenous fluid
was not found to be a related factor causing PONV
(p = 0.404); however, female gender was a factor
influencing the risk of thirst [Crude OR 2.603
(1.257-5.391), P-value 0.01] and dizziness [Crude
OR 3.882 (1.31-11.504), P-value 0.014).
Conclusions: No significant relationship between
amount of IV fluid and risk of PONV and PDNV
was found in ambulatory surgical patients in
Ramathibodi Hospital.

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