A comparative study of postoperative sore throat following insertion of laryngeal mask airway applied with water-soluble gel versus benzydamine hydrochloride spray
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Abstract
Background: Sore throat is a common post-
operative complaint. The etiology of postoperative sore
throat (POST) after insertion of a laryngeal mask
airway (LMA) is the result of damage to airway
mucosa. Objectives: To evaluate the effect of
benzydamine hydrochloride (BH) sprayed on the
LMA cuff in prevention of POST Methods: Fifty
ASA status I-II patients were randomly divided into
two groups. In the BH group, 4 puffs of BH and water-
soluble gel were applied to the LMA cuff, while in the
control group, only water-soluble gel was lubricated.
The semi-inflated LMA was inserted by standard
technique and the cuff was inflated to a leak pressure
of 20 cmH2O. After the surgery, the LMA was removed
when the patient was awake. The incidence and
severity of POST were recorded at the 1st, 2nd, and
4th hour postoperatively. BH-related side effects were
also assessed. Results: Compared with the control
group, the incidence of POST at rest was significantly
less in the BH group at the 1st and 2nd hour postoperatively
(12% vs 44%, p=0.041 and 4% vs 36%, p=0.018,
respectively). The incidence of POST on swallowing
was also significant less in the BH group at 1st and
2nd hour postoperatively (32% vs 60%, p=0.027 and
20% vs 52%, p=0.041, respectively). However, at 4th
hour postoperatively, the incidence of POST at rest
and on swallowing was lower in the BH group but
no statistical significance was demonstrated (4% vs
16%, p=0.333 and 5% vs 11%, p=0.155, respectively).
Dry mouth was the only observed side effect and was
comparable in both groups. Conclusion: Application
of BH and water-soluble gel on the LMA cuff
decreases the incidence of POST at rest and on
swallowing at the 1st and 2nd hour after surgery
without increasing BH-related side effects.
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