Analgesic efficacy of preoperative administration of low-dose pregabalin in patients undergoing breast cancer surgery

Main Article Content

Athitarn Earsakul


Background: Effective acute pain management
with modest adverse effects is important to early
recovery and mobilization in patients undergoing
breast cancer surgery. The pathologic mechanisms
include nociceptive and neuropathic pathway.
Administration of different types of analgesics may
provide synergistic effects to reduce postoperative pain.
Objectives: To investigate the analgesic efficacy
and opioid-sparing effects of a single low-dose
pregabalin in this patients undergoing breast cancer
surgery. Methods: Thirty-two ASA status I-II
patients undergoing modified radical mastectomy
or mastectomy with axillary lymph node dissection,
were recruited and allocated into 2 groups in this
prospective, randomized placebo controlled, double-
blind study to either receive oral pregabalin 75 mg or
a matching placebo 1 hour before surgery. Postoperative
pain (static and dynamic) was assessed by numeric
verbal rating scale (NRS) (0 = pain and 10 = worst
imaginable pain). NRS scores for pain, patient-
controlled morphine consumption and side effects
were recorded at postoperative care unit (PACU), 6 hour,
12 hour, 24 hour, and 48 hour after surgery. Results:
Comparing with the placebo group, NRS pain scores
at rest were significantly lower in the pregabalin
group at 12 hour and 24 hour after surgery (0 vs 1,
p=0.019 and 0 vs 1, p=0.013), whereas NRS pain scores
on movement were similar. Cumulative patient-
controlled morphine consumption and side effects
were comparable between both groups. Conclusion:
Preoperative administration of pregabalin 75 mg
improved postoperative pain at rest 12 hour and 24 hour
after breast cancer surgery without increasing side

Article Details

Original articles


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