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Background: General anesthesia promote impaired pulmonary gas exchange and contribute to postoperative pulmonary complications. Different methods of PEEP titration make the different value of intraoperative oxygenation. Objectives: To study the effect of PEEP titration on the change of intraoperative oxygenation in non-laparoscopic surgery during balanced general anesthesia between dynamic compliance directed PEEP group and conventional PEEP group. Methods: Single-blind randomized controlled trial was done from 1 July 2020 -1 February 2021. After intubation and arterial line insertion. We compared the difference of PaO2 , A-a gradient in arterial blood gas and peak airway pressure at 1st-5th minute and 10th-15th minute between dynamic compliance directed PEEP group and conventional PEEP group. Results: Thirty patients were enrolled in this study. PaO2 at 10th-15th minute in dynamic compliance directed PEEP titration group was higher than the conventional PEEP group (P-value = 0.001). A-a gradient at 10th-15th minute in dynamic compliance directed PEEP group was lesser than the conventional group (P-value = 0.001) Conclusion: Dynamic compliance directed PEEP improve intraoperative oxygenation better than conventional PEEP.
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