Cannabinoids: Do They have Clinical Usefulness for Pain Relief?

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Sasikaan Nimmaanrat
Khomapak Maneewat


Cannabis (marijuana) is the most popular psychoactive substance in the world. Cannabis is now a center of attention in many countries because of its roles for recreational and medicinal purposes. There are at least 500 cannabinoids found in cannabis, of which 104 of them have been identified. Among all cannabinoids, Δ9 tetrahydrocannabinol (THC) is the best known ingredient. THC is the dominant psychoactive component in plant-based marijuana or Cannabis sativa. Cannabidiol (CBD) is a main non-psychoactive (non-intoxicating) and potentially therapeutic component of cannabis. Studies reveal a more favorable analgesic benefit of cannabinoids in animals compared to humans. The benefits of cannabinoids in treating many conditions of chronic pain are uncertain as there is no good evidence to show its favorable analgesic effect.


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