Efficiency of Pre-extubation Intravenous Lidocaine on Peri-extubation Cough

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Patchamon Sathonsaowaapak
Thidarat Ariyanuchitkul
Nattiya Chumnaseaw


Background: General anesthesia is common practice with endotracheal tube. Lidocaine has been added for smoothly intubation and extubation. Objective: To compare peri-extubation cough with and without the use of intravenous lidocaine. Methods: This is a prospective randomized double blind control study in 140 patients which divided into 2 groups; the group received intravenous lidocaine at a dose of 1.5 mg/kg 5 min prior to extubation and the group received intravenous normal saline 5 min pre-extubation period. Primary outcome was incidence of peri-extubation cough. Results: The incidence of peri-extubation cough in the two groups was not significantly different (70% vs 65.7%; p = 0.718). The incidence of sore throat also not different but incidence of lidocaine toxicity was higher in the lidocaine group. Conclusion: Intravenous lidocaine 1.5 mg/kg prior to tracheal extubation was no significantly to cough suppression in peri-extubation period when compared with no drug used.

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