Rate and Factors Related to Postoperative Intensive Care Unit (ICU) Utilization in Elective Gynecologic Oncology Patients

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Sirima Phoowanakulchai
Yamolpat Jirauraipong
Suneerat Kongsayreepong
Suwanit Therasakvichya
Patchareya Nivatpumin
Pawit Somnuke

Abstract

Background: ICU has played an important role in taking care of patients scheduled for oncologic gynecology surgery; however, information regarding utilization of critical care services and the outcomes of these patients is not well established, particularly in Siriraj hospital. Most of these patients also have medical comorbidities, contributing to complications. Objective: To determine the rate and factors related to postoperative ICU admission among gynecologic oncology patients with the beforehand ICU reservations and to report the postoperative outcomes. Materials and Methods: The retrospective single-center study was conducted by reviewing patient charts from April 2013 to March 2020. Preoperative characteristics and intra-and postoperative events were analyzed using logistic regression analysis. Results: A total of 321 patients who underwent preoperative ICU reservation with complete medical records were collected. Most of the patients aged <65 years (62.3%) and had American Society of Anesthesiologists (ASA) physical status ≥ III (71.3%). Total confirmed postoperative ICU admissions were 90 cases (28%). Factors related to ICU admission included preoperative serum albumin level <3.45 g/dl, intraoperative blood loss >800 ml and urine output <0.5 ml/kg/h. Most common indication of ICU admission and postoperative complication were postoperative observation (48.9%) and acute kidney injury (AKI) (36.7%), respectively. Conclusion: Albeit low rate of gynecologic oncology patients requiring postoperative ICU admission, vigilant patient evaluation before ICU admission is paramount. This study provides predictors that can be implemented in future guideline for postoperative ICU admission to save the healthcare resources and preserve ICU space for the patients in need.

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References

Ruskin R, Urban RR, Sherman AE, et al. Predictors of intensive care unit utilization in gynecologic oncology surgery. Int J Gynecol Cancer. 2011;21:1336-42.

Brooks SE, Ahn J, Mullins CD, Baquet CR. Resources and use of the intensive care unit in patients who undergo surgery for ovarian carcinoma. Cancer. 2002;95:1457-62.

Heinonen S, Tyrväinen E, Penttinen J, Saarikoski S, Ruokonen E. Need for critical care in gynaecology: a population-based analysis. Crit Care. 2002;6:371.

Amir M, Shabot MM, Karlan BY. Surgical intensive care unit care after ovarian cancer surgery: an analysis of indications. Am J Obstet Gynecol. 1997;176:1389-93.

Ross MS, Burriss ME, Winger DG, Edwards RP, Courtney-Brooks M, Boisen MM. Unplanned postoperative intensive care unit admission for ovarian cancer cytoreduction is associated with significant decrease in overall survival. Gynecol Oncol. 2018;150:306-10.

American Thoracic Society Bioethics Task Force. Fair allocation of intensive care unit resources. Am J Respir Crit Care Med 1997;156:1282-301.

Cardoso LTQ, Grion CMC, Matsuo T, et al. Impact of delayed admission to intensive care units on mortality of critically ill patients: a cohort study. Crit Care. 2011;15:R28.

O’Callaghan DJP, Jayia P, Vaughan-Huxley E, et al. An observational study to determine the effect of delayed admission to the intensive care unit on patient outcome. Crit Care. 2012;16:R173.

Bing-Hua YU. Delayed admission to intensive care unit for critically surgical patients is associated with increased mortality. Am J Surg. 2014;208:268-74.

Aitavaara-Anttila M, Liisanantti JH, Raatiniemi L, Ohtonen P, Ala-Kokko T. Factors related to delayed intensive care unit admission from

emergency department-a retrospective cohort study. Acta Anaesthesiol Scand. 2019;63:939-46.

Li D, Bohringer C, Liu H. What is “normal” intraoperative blood pressure and do deviations from it really affect postoperative outcome? J Biomed Res. 2017;31:79-81.

Cheung CC, Martyn A, Campbell N, et al. Predictors of intraoperative hypotension and bradycardia. Am J Med. 2015;128:532-8.

Uakritdathikarn T, Chongsuvivatwong V, Geater AF, Vasinanukorn M, Thinchana S, Klayna S. Perioperative desaturation and risk factors in

general anesthesia. J Med Assoc Thai. 2008;91:1020-9.

Thygesen K, Alpert JS, Jaffe AS, et al. Forth universal definition of myocardial infarction (2018). Glob Heart. 2018;13:305-38.

Sacco RL, Kasner SE, Broderick JP, et al. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44: 2064-89.

Kidney disease: improving global outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2013;3:1-150.

Falcao ALE, Barros AGA, Bezerra AAM, et al. The prognostic accuracy evaluation of SAPS 3, SOFA and APACHE II scores for mortality prediction in the surgical ICU: an external validation study and decision-making analysis. Ann Intensive Care. 2019;9:18.

Harris PA, Taylor R, Thielke R, et al. Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42:377-81.

Gregório A, Pais-de-Lacerda A, França C. Is the ASA physical status classification system a good prognostic index for ICU admissions? Crit Care. 2011;15:462.

White ST, Cardenas YR, Nates JL. What every intensivist should know about intensive care unit admission criteria. Rev Bras Ter Intensiva. 2017;29:414-7.

Nates JL, Nunnally M, Kleinpell R, et al. ICU admission, discharge, and triage guidelines: a framework to enhance clinical operations, development of institutional policies, and further research. Crit Care Med. 2016;44:1553-602.

Davidovic-Grigoraki M, Thomakos N, Haidopoulos D, Vlahos G, Rodolakis A. Do critical care units play a role in the management of gynaecological oncology patients? The contribution of gynaecologic oncologist in running critical care units.

Eur J Cancer Care. 2017;26:e12438.

Koukoubanis K, Bibasi V, Thomakos N. The fundamental role of postoperative critical care in gynecologic oncology surgery: a brief report. Ann Colorectal Res. 2020;8:97-100.

Leath 3rd CA, Kendrick 4th JE, Numnum TM, et al. Outcomes of gynecologic oncology patients admitted to the intensive care unit following surgery: a university teaching hospital experience. Int J Gynecol Cancer. 2006;16:1766-9.

Namendys-Silva SA, González-Herrera MO, Texcocano-Becerra J, et al. Outcomes of critically ill gynecological cancer patients admitted to intensive care unit. Am J Hosp Palliat Care. 2013;30:7-11.

Pepin K, Bregar A, Davis M, et al. Intensive care admissions among ovarian cancer patients treated with primary debulking surgery and neoadjuvant chemotherapy-interval debulking surgery. Gynecol Oncol. 2017;147:612-6.

Thomakos N, Prodomidou A, Haidopoulos D, Machairas N, Rodolakis A. Postoperative admission in critical care units following gynecologic oncology surgery: outcomes based on a systematic review and authors’ recommendations. In Vivo. 2020;34:2201-8.

National center for health statistics, center for disease control and prevention. Measured average height, weight, and waist circumference for adults ages 20 and over, https://www.cdc.gov/nchs/fastats/body-measurements.html; 2021 [accessed 14 May 2021].

Thailand Board of Investment. “Size Thailand”: the standard sizes of Thai people, https://www.boi.go.th/un/boi_event_detail? module=news&topic_id=4099; 2017 [accessed 14 May 2021].

Kumar P, Renuka MK, Kalaiselvan MS, Arunkumar AS. Outcome of noncardiac surgical patients admitted to a multidisciplinary intensive care unit. Indian J Crit Care Med. 2017;17:17-22.

Thomakos N, Zacharakis D, Rodolakis A, et al. Gynecologic oncology patients in the surgical high dependency unit: an analysis of indications. Arch Gynecol Obstet. 2014;290:335-9.

Diaz-Montes TP, Zahurak ML, Bristow RE. Predictors of extended intensive care unit resource utilization following surgery for ovarian cancer. Gynecol Oncol. 2007;107:464-8.