Cannabis: What Anesthesiologists Need to Know?
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Abstract
Cannabis is categorized as an abuse drug that is not able to be studied, and has now been legalized in Thailand. The physiology and pharmacology of cannabis in humans are also difficult to study. The most famous of cannabinoids are THC (delta-9-tetrahydrocannabinol) and CBD (cannabidiol).1 THC is the most potent psychoactive product. It is mainly found in the flowering buds of the cannabis plant. The half-life of THC in the human body is 5-13 days. The effects of cannabis are difficult to expect because they depend on both THC concentration and the route of delivery. CBD is not psychoactive, and is a product marketed for antianxiety and chronic pain problems. To date, anesthesiologists need to understand the pharmacodynamics and pharmacokinetics of the use of cannabis and its chemical compounds. Inhaled cannabinoids are rapidly distributed within seconds to minutes after an inhaled dose. The effects of orally ingested cannabinoids may be delayed up to 1-2 hours
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References
Amornyotin S. Cannabis and endocannabinoid system. J Addict Med Ther Sci. 2021;7:004-6.
Jouanjus E, Raymond V, Lapeyre-Mestre M, Wolff V. What is the current knowledge about the cardiovascular risk for users of cannabis-based products? A systematic review. Curr Atheroscler Rep. 2017;19:26.
Hitchcock LN, Tracy BL, Bryan AD, Hutchison KE, Bidwell LC. Acute effects of cannabis concentrate on motor control and speed: smartphone-based mobile assessment. Front Psychiatry. 2020;11:623672.
Chetty K, Lavoie A, Deghani P. A literature review of cannabis and myocardial infarction-what clinicians may not be aware of. CJC Open. 2020;3:12-21.
Huson H, Granados T, Rasko Y. Surgical considerations of marijuana use in elective procedures. Heliyon. 2018;4:e00779..
Beaulieu P, Boulanger A, Desroches J, Clark AJ. Medical cannabis: considerations for the anesthesiologist and pain physician. Can J Anesth. 2016;63:608-24.
Flisberg P, Paech MJ, Shah T, Ledowski T, Kurowski I, Parsons R. Induction dose of propofol in patients using cannabis. Eur J Anaesthesiol. 2009;26:192-5.
Ibera C, Shalom B, Saifi F, Shruder J, Davidson E. Effects of cannabis extract premedication on anesthetic depth. Harefuah. 2018;157:162-6.
Beaulieu P. Anesthetic-implications of recreational drug use. Can J Anesth. 2017;64:1236-64.
Echeverria-Villalobos M, Todeschini AB, Stoicea N,
Fiorda-Diaz J, Weaver T, Bergese SD. Perioperative care of cannabis users: a comprehensive review of pharmacological and anesthetic considerations. J Clin Anesth. 2019;57:41-9.
McAfee J, Boehnke KF, Moser SM, Brummett CM, Waljee JF, Bonar EE. Perioperative cannabis use: a longitudinal study of associated clinical characteristics and surgical outcomes. Reg Anesth Pain Med. 2021;46:137-44.