Effect of 5% Carbogen on Patient Safety during Blood Oxygen Level-Dependent Magnetic Resonance Imaging with Cerebrovascular Carbon Dioxide Reactivity Test

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Pimwan Sookplung
Punjama Lertbutsayanukul
Phuping Akavipat


Introduction: Preoperative evaluation andseverity assessment of cerebrovascularinsufficiency using the blood oxygen level-
dependent MR imaging (BOLD MRI) technique with the cerebrovascular reactivity test (CVR) using inhale carbogen gas is a new method in Thailand. There is a lack of information on the response of end-tidal carbon dioxide (ETCO2), the success of the examination, problems, and safety during the examination.
Materials and Methods: This study is a descriptive observational study in outpatients who underwent a BOLD MRI with CO2 reactivity test at the Neurological Institute of Thailand.
Results: Twenty-nine patients, 41 BOLD MRI with CVR test. Patients with Moya-Moya disease are frequently undergoing BOLD MRI with CVR test. At all intervals of inhaled carbogen, only the ETCO2 value was significantly changed compared with the initial ETCO2 value. During the examination, no complications were found.
Conclusions: The BOLD MRI with CO2 reactivity test is safe. However, the anesthesiologist should understand the principle of cerebrovascular reactivity and select the proper equipment to prepare for the examination.

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