Effect of 0.3% Benzydamine Hydrochloride Spray and 10% Lidocaine Spray on Postoperative Sore Throat after General Anesthesia with Endotracheal Intubation: a Prospective Randomized Controlled Trial
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Abstract
Background: Postoperative sore throat (POST) is the most common airway-related complication after endotracheal extubation. POST has an affect on patient’s satisfaction. The objective of the study is to compare the effects of 0.3% benzydamine hydrochloride spray and 10% lidocaine spray on postoperative sore throat score in first 24 hour after general tracheal anesthesia, and to compare the side effects including hoarseness, cough, dysphagia, and nausea/vomiting after general anesthesia. Methods: This study was a prospective randomized controlled trial. A total of 165 patients was randomly allocated into 3 groups. Group A 0.3% benzydamine hydrochloride spray (n=56), group B 10% lidocaine spray (n=54) and group C normal saline solution (n=55) was applied to the cuffed endotracheal tube before intubation. Patients were examined for postope-rative sore throat score, hoarseness, cough, dysphagia and nausea/vomiting at 1, 6, 12 and 24 hours after extubation. Results: 0.3% benzydamine hydrochloride spray and 10% lidocaine spray could decrease postoperative sore throat in first 24 hour after surgery but there was not significantly different between groups (A/B, A/C, and B/C) at 1, 6, 12 and 24 hours after extubation. With 10% lidocaine spray, coughing was observed at 1 h after extubation (P=0.019). With 0.3% benzydamine hydrochloride spray, nausea/vomiting was observed at 6 h after extubation (P=0.015). Conclusion: 0.3% benzydamine hydrochloride spray, 10% lidocaine spray and normal saline solution applied to endotracheal cuff tube can reduce postoperative sore throat in first 24 hour after tracheal extubation. However, 0.3% benzydamine hydrochloride spray and 10% lidocaine spray could not prevent hoarseness and dysphagia after extubation.
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