Remimazolam: What Is It?

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Somchai Amornyotin


Remimazolam (CNS 7056) is a new rapidly metabolized benzodiazepine and has been presented in clinical research protocols. It is water-soluble and when diluted into a solution becomes a painless injectate. Remimazolam is most soluble in slightly acidic environments and can precipitate in lactated or acetated Ringer’s solution.1 It has promising characteristics as a sedative drug in clinical anesthesia because of its rapid onset of action, ultra short duration, and fast recovery time. Midazolam is the parent compound of remimazolam; therefore, remimazolam has a gamma-aminobutyric acid (GABA) neurotransmitter receptor mechanism of action. Remimazolam is rapidly metabolized by non-specific esterases, mainly localized in the human liver. After administration, plasma concentrations of remimazolam certainly and rapidly decrease, and with adequate dosing, there is no prolonged sedative effect.

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