Efficacy of Lubrication of the Laryngeal Mask Airway with Benzydamine Hydrochloride Spray versus Chamomile Extract Spray for Prevention of Postoperative Sore Throat: a Randomized Controlled Trial
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Abstract
Background: Despite the i-gel® being considered less traumatic to the airway, the incidence of postoperative sore throat (POST) remains high. Various drugs, including benzydamine hydrochloride (BH) spray, have been studied for their ability to reduce POST, but no studies have examined the efficacy of chamomile extract spray. This study aims to compare the efficacy of BH and chamomile extract sprays in reducing the incidence of POST after general anesthesia (GA) with the i-gel®. Methods: In this randomized controlled trial, a total of 228 patients undergoing surgery under GA with the i-gel® were assigned into one of three groups. Prior to induction of anesthesia, the i-gel® was sprayed with 4 puffs of BH, chamomile extract, or normal saline in the BH, chamomile, and control groups, respectively. The primary objective of the study was to compare the incidence of POST among the three groups at 1, 4, and 24 hours after surgery. Results: The study found that the incidence of sore throat was significantly different at the 4th hour postoperatively, being lowest (28.4%) in the chamomile group and highest (50.0%) in the control group (P=0.023). Moreover, the severity of sore throat was significantly different between the chamomile and control groups at the 4th postoperative hour (P=0.015), while chamomile demonstrated greater efficacy than BH in reducing POST (RRR 43.0%, 15.0%, respectively). Conclusion: Spraying 4 puffs of chamomile extract on the i-gel® before insertion effectively reduces incidence and severity of POST at 4-hour post-surgery
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