Xanthones from Garcinia mangostana inhibit the proliferation and migration of hepatocellular carcinoma cells

Authors

  • Kedkran Koopklang Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
  • Siwattra Choodej Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
  • Natthaya Chuaypen Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
  • Khanitha Pudhom Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand

Keywords:

xanthone, Garcinia mangostana, cell proliferatin, cell migration

Abstract

Hepatocellular carcinoma (HCC) accounts for more than 90% of liver cancer cases worldwide and is the most common cancer in men in Thailand. Here, we investigated the effect of five xanthones isolated from Garcinia mangostana root on the proliferation and migration of human HCC cell lines. We identified five xanthones, among which the prenylated xanthones 1–3 had significant anti-proliferative effects on both Hep-G2 and Huh-7 cell lines, with 50% inhibitor concentrations (IC50) ranging from 5.9 μM to 15.0 µM. In contrast, the simple xanthones 4 and 5 were inactive (IC50 >50 µM), implying that the prenyl moiety is required for the inhibitory activity. Exposure of HCC cells to 1 and 2 (α- and β-mangostin) also suppressed cell migration, a crucial step in metastasis.

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Published

2021-01-15

How to Cite

1.
Koopklang K, Choodej S, Chuaypen N, Pudhom K. Xanthones from Garcinia mangostana inhibit the proliferation and migration of hepatocellular carcinoma cells. J Chulabhorn Royal Acad [Internet]. 2021 Jan. 15 [cited 2024 May 9];3(1):40-8. Available from: https://he02.tci-thaijo.org/index.php/jcra/article/view/247333

Issue

Vol. 3 No. 1 (2021): January - March

Section

Research Articles

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