Effects of Music Therapy on a Gastrointestinal and Fatigue Symptom Cluster in Breast Cancer Patients Undergoing Chemotherapy

Authors

  • Jesadaporn Wongkapin School of Nursing, Rangsit University
  • Kanitha Hanprasitkam School of Nursing, Rangsit University
  • Rachanee Namjuntra School of Nursing, Rangsit University

Keywords:

มะเร็งเต้านม, เคมีบำบัด, กลุ่มอาการทางเดินอาหารและอาการเหนื่อยล้า, ดนตรีบำบัด

Abstract

Breast cancer patients receiving chemotherapy often experience a gastrointestinal and fatigue symptom cluster. This symptom cluster had the greatest impact on their quality of life. Music therapy is a safe and low-cost approach for symptom management. This quasi-experimental two-group comparative study aimed to examine the effects of music therapy on the severity and distress of the gastrointestinal and fatigue symptom cluster among breast cancer patients receiving chemotherapy. Fifty participants were randomly assigned to a control group (n = 25) receiving standard nursing care and an experimental group (n = 25) receiving standard care combined with music therapy for 30 minutes per day for 21 consecutive days after chemotherapy. Research instruments included a demographic questionnaire and a symptom severity and distress assessment form (Cronbach’s alpha = 0.92). Data were collected at baseline (D0), days 1–7 (D1–D7), day 14 (D14), and day 21 (D21). Data were analyzed using two-way repeated measures ANOVA. The results showed no significant differences between groups at baseline. After the intervention, the experimental group had significantly lower severity and distress scores than the control group (p < .001), and the pattern of change in distress differed significantly between groups over time (p < .05). In conclusion, the findings indicate that music therapy can be integrated as a nursing approach to enhance the management of a gastrointestinal and fatigue symptom cluster in breast cancer patients undergoing chemotherapy.



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References

World Health Organization. Breast cancer: key facts.. https://www.who.int/news-room/fact-sheets/detail/breast-cancer. Accessed October 21, 2025.

กองยุทธศาสตร์และแผนงาน สำนักงานปลัดกระทรวงสาธารณสุข. รายงานมาตรฐานข้อมูลเพื่อตอบสนอง Service Plan สาขาโรคมะเร็ง: มะเร็งเต้านม. https://hdc.moph.go.th/pbi/public/standard-report-detail/825c7fbfdbde936cf821a9b16dc4189b. Accessed February 18, 2025.

กองยุทธศาสตร์และแผนงาน สำนักงานปลัดกระทรวงสาธารณสุข. รายงานสถิติสาธารณสุข พ.ศ. 2567. นนทบุรี: กองยุทธศาสตร์และแผนงาน สำนักงานปลัดกระทรวงสาธารณสุข: 2567.

Nardin S, Mora E, Varughese FM, et al. Breast cancer survivorship, quality of life, and late toxicities. Front Oncol. 2020;10:864. doi:10.3389/fonc.2020.00864

American Cancer Society. Chemotherapy side effects. https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/chemotherapy/chemotherapy-side-effects.html. Accessed October 21, 2025.

Kim HJ, McGuire DB, Tulman L, Barsevick AM. Symptom clusters: concept analysis and clinical implications for cancer nursing. Cancer Nurs. 2005;28(4):270-282. doi:10.1097/00002820-200507000-00005

Lenz ER, Pugh LC, Milligan RA, Gift AG, Suppe F. The middle-range theory of unpleasant symptoms: an update. Adv Nurs Sci. 1997;19(3):14-27. doi:10.1097/00012272-199703000-00003

Suwisith N, Hanucharurnkul S, Dodd M. Symptom Clusters and Functional Status of Women with Breast Cancer. Pac Rim Int J Nurs Res. 2008;12(3):153-165.

Phligbua W, Suwisith N, Kongvattananon P. Symptom clusters and quality of life in women with breast cancer receiving adjuvant chemotherapy. Pac Rim Int J Nurs Res. 2013;17(3):224-237.

Albusoul RM, Berger AM, Gay CL, Janson SL, Lee KA. Symptom clusters change over time in women receiving adjuvant chemotherapy for breast cancer. J Pain Symptom Manage. 2017;53(5):880-886. doi:10.1016/j.jpainsymman.2016.12.332

Herrstedt J, Clark-Snow R, Ruhlmann CH, et al. 2023 MASCC and ESMO guideline update for the prevention of chemotherapy-and radiotherapy-induced nausea and vomiting. ESMO Open. 2024;9(1):103669. doi:10.1016/j.esmoop.2023.102195

สุธาร จันทะวงศ์. การป้องกันภาวะคลื่นไส้อาเจียนจากยาเคมีบำบัด. ศรีนครินทร์เวชสาร. 2562;34(1):115-126.

Atkinson TM, Liou KT, Borten MA, et al. Association between music therapy techniques and patient-reported moderate to severe fatigue in hospitalized adults with cancer. JCO Oncol Pract. 2020;16(12):e1553-e1557. doi:10.1200/OP.20.00096

Rosenow SC, Silverman MJ. Effects of single session music therapy on hospitalized patients recovering from a bone marrow transplant: Two studies. Arts Psychother. 2014;41(1):65-70. doi:10.1016/j.aip.2013.11.003

Bradt J, Dileo C, Myers-Coffman K, Biondo J. Music interventions for improving psychological and physical outcomes in cancer patients. Cochrane Database Syst Rev. 2020;10:CD006911. doi:10.1002/14651858.CD006911.pub3

Chanda ML, Levitin DJ. The neurochemistry of music. Trends Cogn Sci. 2013;17(4):179-193. doi:10.1016/j.tics.2013.02.007

Chen SC, Yeh ML, Chang HJ, Lin MF. Music, heart rate variability, and symptom clusters: a comparative study. Support Care Cancer. 2020;28:351-360. doi:10.1007/s00520-019-04817-x

อาริยา สอนบุญ. ผลของดนตรีบำบัดต่อความวิตกกังวลและอาการคลื่นไส้อาเจียนในผู้ป่วยมะเร็งเต้านมที่ได้รับยาเคมีบำบัด. วิทยานิพนธ์พยาบาลศาสตรมหาบัณฑิต. มหาวิทยาลัยขอนแก่น; 2543.

Khuntee W, Hanprasitkam K, Sumdaengrit B. Effect of music therapy on postembolization syndrome in Thai patients with hepatocellular carcinoma: A quasi-experimental crossover study. Belitung Nurs J. 2022;8(5):396-404. doi:10.33546/bnj.2210

Schmider E, Ziegler M, Danay E, Beyer L, Bühner M. Is it really robust? Reinvestigating the robustness of ANOVA against violations of the normal distribution assumption. Methodology. 2010;6(4):147-151. doi:10.1027/1614-2241/a000016

Blanca MJ, Alarcón R, Arnau J, Bono R, Bendayan R. Non-normal data: Is ANOVA still a valid option? Psicothema. 2017;29(4):552-557. doi:10.7334/psicothema2016.383

Hesketh PJ. Chemotherapy-induced nausea and vomiting. N Engl J Med. 2008;358(23):2482-2494. doi:10.1056/NEJMra0706547

Hsu HT, Lin KC, Wu LM, et al. Symptom cluster trajectories during chemotherapy in breast cancer outpatients. J Pain Symptom Manage. 2017;53(6):1017-1025. doi:10.1016/j.jpainsymman.2016.12.354

Janelsins MC, Tejani MA, Kamen C, Peoples AR, Mustian KM, Morrow GR. Current pharmacotherapy for chemotherapy-induced nausea and vomiting in cancer patients. Expert Opin Pharmacother. 2013;14(6):757-766. doi:10.1517/14656566.2013.776541

Koelsch S. Brain correlates of music-evoked emotions. Nat Rev Neurosci. 2014;15(3):170-180. doi:10.1038/nrn3666

Lima TU, Moura ECR, Oliveira CMB, et al. Impact of a music intervention on quality of life in breast cancer patients undergoing chemotherapy: a randomized clinical trial. Integr Cancer Ther. 2020;19:1534735420938430. doi:10.1177/1534735420938430

Pozhhan M, Sobhani S, Rasouli AS, Tohidinezhad F. The effect of music therapy on chemotherapy-induced nausea and vomiting in women with breast cancer. Indian J Cancer. 2023;60(1):87-91. doi:10.4103/ijc.IJC_535_19

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Published

2026-05-20

How to Cite

1.
Wongkapin J, Hanprasitkam K, Namjuntra R. Effects of Music Therapy on a Gastrointestinal and Fatigue Symptom Cluster in Breast Cancer Patients Undergoing Chemotherapy. J Chulabhorn Royal Acad [internet]. 2026 May 20 [cited 2026 May 25];8(3):232-4. available from: https://he02.tci-thaijo.org/index.php/jcra/article/view/279081

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Research Articles