Use of antiseptic solutions in traumatic wound care
คำสำคัญ:
Traumatic wound care, Antiseptic solutions, Microorganisms, Wound healingบทคัดย่อ
Traumatic wounds, resulting from accidents or injuries, carry a high risk of infection due to the introduction of pathogens into the body. Therefore, effective wound care is essential to promote healing and prevent complications. A key component of wound management is the use of antiseptic solutions, which work through various mechanisms to curb microbial growth. This includes disrupting cell membranes, denaturing proteins, and interfering with metabolic processes. Moreover, these solutions have broad-spectrum activity against a wide range of microorganisms, including bacteria, fungi, and viruses.
The application of antiseptic solutions requires thoughtful consideration. This involves choosing an appropriate antiseptic, determining the optimal concentration, and using the most effective application method. These factors are critical in ensuring optimal efficacy and maintaining patient safety. Additionally, selection of an appropriate antiseptic should also involve consideration of wound type, patient characteristics, and underlying medical conditions.
Further research is essential to optimize antiseptic selection, establish appropriate dosing regimens, and enhance application techniques in wound care. By advancing wound care practices, researchers aim to enhance patient outcomes in the field of traumatic wound management.
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Yousefian F, Hesari R, Jensen T, et al. Anti-microbial Wound Dressings: A Concise Review for Clinicians. Antibiotics (Basel). 2023;12(9) doi:10.3390/antibiotics 12091434
Babalska Z, Korbecka-Paczkowska M, Karpinski TM. Wound Antiseptics and European Guidelines for Antiseptic Application in Wound Treatment. Pharmaceuticals (Basel). 2021;14(12) doi:10.3390/ph14121253
Bednarek RS, Nassereddin A, Ramsey ML. Skin Antiseptics. StatPearls. StatPearls Publishing LLC.; 2023.Sahiner A, Halat E, Yapar EA, Kara BA.
Evaluation of organic load-related efficacy changes in antiseptic solutions used in hospitals. Turk J Med Sci. 2022;52(3):825-833. doi:10.55730/1300-0144.5379
Zebley JA, Klein A, Wanersdorfer K, et al. 0.05% Chlorhexidine Gluconate Irrigation in Trauma/Emergency General Surgical Laparotomy Wounds Closure: A Pilot Study. J Surg Res. 2024;293:427-432. doi:10.1016/j.jss.2023.09.016
Luwang AL, Saha PK, Rohilla M, Sikka P, Saha L, Gautam V. Chlorhexidine-alcohol versus povidone-iodine as preoperative skin antisepsis for prevention of surgical site infection in cesarean delivery-a pilot randomized control trial. Trials. 2021;22(1):540. doi:10.1186/s13063-021-05490-4
Lepelletier D, Maillard JY, Pozzetto B, Simon A. Povidone Iodine: Properties, Mechanisms of Action, and Role in Infection Control and Staphylococcus aureus Decolonization. Antimicrob Agents Chemother. 2020;64(9) doi:10.1128/ aac.00682-20
Oropallo A, Rao AS, Del Pin C, Ranire-Maguire M, Mathew A. An objective comparative study of non-surgical cleansing techniques and cleanser types in bacterial burden management. Int Wound J. 2024;21(2):e14730. doi:10.1111/iwj.14730
Rai S, Gupta TP, Shaki O, Kale A. Hydrogen Peroxide: Its Use in an Extensive Acute Wound to Promote Wound Granulation and Infection Control - Is it Better Than Normal Saline. Int J Low Extrem Wounds. 2023;22(3):563-577. doi:10.1177/15347346211032555
Zhu G, Wang Q, Lu S, Niu Y. Hydrogen Peroxide: A Potential Wound Therapeutic Target? Med Princ Pract. 2017;26(4):301-308. doi:10.1159/000475501
Urban MV, Rath T, Radtke C. Hydrogenperoxide (H(2)O(2)): a review of its use in surgery. Wien Med Wochenschr. 2019;169(9-10):222-225. doi:10.1007/s10354-017-0610-2
Hoang TPN, Ghori MU, Conway BR. Topical Antiseptic Formulations for Skin and Soft Tissue Infections. Pharmaceutics. 2021;13(4) doi:10.3390/pharmaceutics 13040558
Radek KA, Ranzer MJ, DiPietro LA. Brewing complications: the effect of acute ethanol exposure on wound healing. J Leukoc Biol. 2009;86(5):1125-34. doi:10.1189/jlb.0209103
Alves PJ, Barreto RT, Barrois BM, Gryson LG, Meaume S, Monstrey SJ. Update on the role of antiseptics in the management of chronic wounds with critical colonisation and/or biofilm. Int Wound J. 2021;18(3):342-358. doi:10.1111/iwj.13537
Beraldo S, Ljungqvist J, Rodger R, Hanson B, Saavedra C. Effectiveness of an enhanced silver-containing dressing in hard-to-heal venous leg ulcers: a randomised controlled trial. J Wound Care. 2025;34(3):170-178. doi:10.12968/jowc.2025.0023
Merchel Piovesan Pereira B, Tagkopoulos I. Benzalkonium Chlorides: Uses, Regulatory Status, and Microbial Resistance. Appl Environ Microbiol. 2019;85(13) doi:10.1128/aem.00377-19
Kramer A, Dissemond J, Kim S, et al. Consensus on Wound Antisepsis: Update 2018. Skin Pharmacol Physiol. 2018;31(1):28-58. doi:10.1159/000481545
Soeselo DA, Yolanda R, Zita M, Theresia S, Astiarani Y, Santi BT. Antiseptic versus non-antiseptic solutions for preventing infection in acute traumatic wounds: a systematic review. J Wound Care. 2022;31(2):162-169. doi:10.12968/jowc.2022.31.2.162
Goswami AG, Basu S, Banerjee T, Shukla VK. Biofilm and wound healing: from bench to bedside. Eur J Med Res. 2023;28(1):157. doi:10.1186/s40001-023-01121-7
Barreto R, Barrois B, Lambert J, Malhotra-Kumar S, Santos-Fernandes V, Monstrey S. Addressing the challenges in antisepsis: focus on povidone iodine. Int J Antimicrob Agents. 2020;56(3):106064. doi:10.1016/j.ijantimicag.2020.106064
Carpa R, Remizovschi A, Culda CA, Butiuc-Keul AL. Inherent and Composite Hydrogels as Promising Materials to Limit Antimicrobial Resistance. Gels. 2022;8(2) doi:10.3390/gels8020070
Ricciardi W, Cascini F. Guidelines and safety practices for improving patient safety. In: Donaldson LJ, Ricciardi W, Sheridan S, Tartaglia R, eds. Textbook of patient safety and clincal risk management. Springer; 2021:chap 1.
Oliverius M, Drozd J, Bratka P, Whitley A, Mohlenikova Duchonova B, Gürlich R. A new silver dressing, StopBac, used in the prevention of surgical site infections. Int Wound J. 2022;19(1):29-35. doi:10.1111/iwj.13593
Losi S, Berra CCF, Fornengo R, Pitocco D, Biricolti G, Federici MO. The role of patient preferences in adherence to treatment in chronic disease: a narrative review. Drug Target Insights. 2021;15:13-20. doi:10.33393/dti.2021.2342
Saint-Pierre C, Herskovic V, Sepúlveda M. Multidisciplinary collaboration in primary care: a systematic review. Fam Pract. 2018;35(2):132-141. doi:10.1093/fampra/cmx085
Du X, Zhao J, Ren Q, et al. Clinical application of platelet rich plasma to promote healing of open hand injury with skin defect. Regenerative Therapy. 2024;26:308-314.
Verma R, Kumar S, Garg P, Verma YK. Platelet-rich plasma: a comparative and economical therapy for wound healing and tissue regeneration. Cell and Tissue Banking. 2023;24(2):285-306. doi:10.1007/s10561-022-10039-z
Braný D, Dvorská D, Halašová E, Škovierová H. Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine. Int J Mol Sci. 2020;21(8) doi:10.3390/ijms21082932
Beitia M, Delgado D, Mercader J, Sánchez P, López de Dicastillo L, Sánchez M. Action of Platelet-Rich Plasma on In Vitro Cellular Bioactivity: More than Platelets. Int J Mol Sci. 2023;24(6) doi:10.3390/ijms24065367
Zhang W, Guo Y, Kuss M, et al. Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation. Tissue Eng Part B Rev. 2019;25(3):225-236. doi:10.1089/ten.TEB.2018.0309
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