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Burning mouth syndrome is characterized by the presence of burning sensation in oral cavity without sign of mucosal alteration. Because of the absence of clinical lesion, diagnosis of this abnormality is not straightforward and required combination of several information, including history, physical finding, and laboratory investigation. This article presents a case of patient with a burning sensation and numbness in the tongue. The diagnosis of secondary burning mouth syndrome was suspected. She has been suffering from lymphoproliferative disorder. Laboratory evaluation revealed abnormalities of blood cell production, as well as folate deficiency, which are the factors that cause or predispose to oral burning sensation. One month after taking vitamin supplements, improvement of symptom was achieved.
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