Factors affecting odontogenic keratocyst recurrence: a retrospective chart review
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Objectives: The aim of this study was to assess the association between the sociodemographic, clinical, radiological, and surgical characteristics and odontogenic keratocyst (OKC) recurrence and evaluate the recurrence rate.
Materials and Methods: A retrospective chart review of patients diagnosed and treated for OKC from 2001–2018 was performed using the hospital records. We reviewed the medical records of 129 patients to extract their sociodemographic, clinical features, radiological features, surgical treatment and its characteristics, follow-up period, and re-occurrence information. The parametric numerical variables (age) are described as mean and standard deviation, whereas the categorical variables are presented as frequency and percentage. The association between the socio-demographic, clinical, radiological, and surgical factors and OKC recurrence was assessed using logistic regression. The Nelson-Aalen estimator of survival function in the survival analysis was used to estimate the cumulative hazard of OKC recurrence with time. A p-value <0.05 was considered significant.
Results: Eighty-one patients who were diagnosed and treated for OKC were included in this study after meeting the inclusion criteria. Fifty percent of them were females. The mean age of the patients at diagnosis and treatment for OKC was 28.6 ± 12.6 years old. Among the risk factors, root resorption was significantly associated with OKC recurrence (p=0.004). Removal of teeth associated with root resorption demonstrated a significantly lower risk of recurrence (p=0.031). No other variable had a significant relationship with OKC recurrence. After a 2-year (24 months) follow-up, the recurrence was found in 14 cases with a cumulative probability of 27.5%.
Conclusions: Root resorption due to OKC is significantly associated with an increased recurrence rate. The removal of teeth associated with root resorption resulted in a significantly lower recurrence rate. However, other demographic, clinical, radiological, and surgical factors did not demonstrate significant differences in their OKC recurrence.
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