Challenges in managing plasma cell gingivitis associated with copper sulphate: a case report

Main Article Content

Shu Xhin Tan
Nor Nazaliza Basri
Khamiza Zainol Abidin


Plasma cell gingivitis (PCG) is an infrequent, benign inflammatory condition of the gingiva, marked by diffuse, sub-epithelial plasma cell inflammatory infiltration into the connective tissue. Clinically, it is characterized by sharply demarcated erythematous and edematous gingival conditions, often extending to the mucogingival junction. Although the aetiology of the condition is not properly understood, it may be related to specific allergens, neoplasia, or maybe of unknown origin. Therefore, plaque control and conventional periodontal therapy alone will not treat the condition. Here, we present a 15-year-old lady with PCG, brought on by copper sulphate. The condition is diagnosed based on comprehensive history taking, clinical examination, and laboratory tests, managed by conventional periodontal therapy with adjunctive dexamethasone paste.

Article Details

How to Cite
Tan SX, Basri NN, Zainol Abidin K. Challenges in managing plasma cell gingivitis associated with copper sulphate: a case report. M Dent J [Internet]. 2022 Dec. 13 [cited 2024 Apr. 22];42(3):223-30. Available from:
Case report


Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, et al. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol 2018; 89: S74–S84.

Macleod RI, Ellis JE. Plasma cell gingivitis related to the use of herbal toothpaste. Br Dent J 1989; 166: 375–6.

Kerr DA, McClatchey KD, Regezi JA. Allergic gingivostomatitis (due to gum chewing). J Periodontol 1971; 42: 709–12.

Hedin CA, Karpe B, Larsson A. Plasma-cell gingivitis in children and adults. A clinical and histological description. Swed Dent J 1994; 18: 117–24.

Serio FG, Siegel MA, Slade BE. Plasma cell gingivitis of unusual origin. A Case Report. J Periodontol 1991; 62: 390–3.

Zoon JJ. Chronic circumscribed balanitis with plasma cell infiltration. Ned Tijdschr Geneeskd 1950; 94: 1529–30.

Janam P, Nayar B, Mohan R, Suchitra A. Plasma cell gingivitis associated with cheilitis: A diagnostic dilemma! J Indian Soc Periodontol 2012; 16: 115–9.

Gargiulo AV, Ladone JA, Ladone PA, Toto PD. Case report: plasma cell gingivitis A. CDS Rev 1995; 88: 22–3.

Silverman S Jr, Lozada F. An epilogue to plasma-cell gingivostomatitis (allergic gingivostomatitis). Oral Surgery, Oral Med Oral Pathol 1977; 43: 211–7.

Arduino PG, D’Aiuto F, Cavallito C, Carcieri P, Carbone M, Conrotto D, et al. Professional oral hygiene as a therapeutic option for pediatric patients with plasma cell gingivitis: preliminary results of a prospective case series. J Periodontol 2011; 82: 1670–5.

Arun K, Ambooken M, Varghese SS, Varghese T, Mathew JJ. A rare case of plasma cell mucositis in a young patient. J Indian Soc Periodontol 2017; 21: 63–5.

Leuci S, Coppola N, Adamo N, Bizzoca ME, Russo D, Spagnuolo G, et al. Clinico-pathological profile and outcomes of 45 cases of plasma cell gingivitis. J Clin Med 2021; 10: 830.

Panpradit N, Lapthanasupkul P. Plasma cell gingivitis associated with dry flower buds of clove: a case report. M Dent J 2017; 37: 155–62.

Joshi C, Shukla P. Plasma cell gingivitis. J Indian Soc Periodontol 2015; 19: 221–3.

Mishra MB, Sharma S, Sharma A. Plasma cell gingivitis: An occasional case report. N Y State Dent J 2015; 81: 57–60.

Lim HC, Kim CS. Oral signs of acute leukemia for early detection. J Periodontal Implant Sci 2014; 44: 293–9.

Ghiasi M. Strawberry gingivitis in granulomatosis with polyangiitis. N Engl J Med 2017; 377: 2073.

Menzies S, O’Shea F, Galvin S, Wynne B. Oral manifestations of lupus. Irish J Med Sci 2018; 187: 91–3.

Marker P, Krogdahl A. Plasma cell gingivitis apparently related to the use of khat: report of a case. Br Dent J 2002; 192: 311–3.

Miller RL, Gould AR, Bernstein ML. Cinnamon-induced stomatitis venenata. Clinical and characteristic histopathologic features. Oral Surgery, Oral Med Oral Pathol 1992; 73: 708–16.