The effect of 2% minocycline gel as an adjunct to scaling and root planing at the furcation area in supportive periodontal therapy
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Abstract
Objective: The aim of this study was to evaluate the clinical outcomes of 2% minocycline gel as an adjunct to scaling and root planing and compare them with scaling and root planing alone at the furcation area in treated periodontal patients during supportive periodontal therapy.
Materials and Methods: Patients entering supportive periodontal therapy who had 2 residual pockets equal to or greater than 5 mm at the contralateral side in the furcation area were recruited in a randomized, controlled, single-blinded study. A full-mouth examination comprising probing depth (PD), relative attachment level (RAL), bleeding on probing (BOP), gingival Index (GI), full mouth plaque index (PI), full mouth bleeding index (BI), and furcation involvement (FI) was performed at baseline, day 30 and day 90. The experiment protocol for the control sites was scaling and root planing (SRP) alone while that of the test sites was SRP and the administration of Periocline® at baseline and day 14.
Results: The full mouth PI and BI, RAL, PD, BOP-positive sites, and GI at the 1-month follow-up were improved in both treatment groups. At the 3-month follow-up, adding minocycline as an adjunctive treatment significantly improved RAL and PD. Furthermore, most teeth showed no progression in the degree of FI. In contrast, the SRP alone group demonstrated a relapse in the degree of furcation involvement more frequently than in the SRP along with minocycline group (18.52% vs 3.70%, respectively). However, the degree of furcation involvement was not significantly different among time points within each group and between groups.
Conclusion: Within the limitations of this study, local application of minocycline HCl 2% gel (Periocline®) as an adjunct to scaling and root planing in the furcation area demonstrated significant improvement in clinical parameters (RAL and PD) and reduced inflammation (BOP-positive sites) than scaling and root planing alone at the 3-month follow-up.
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