Clinical effect of 2% minocycline gel as an adjunct to scaling and root planing on single-rooted teeth in supportive periodontal therapy
Article Sidebar
Main Article Content
Abstract
Objective: In supportive periodontitis patients, local minocycline gel is used as an adjunct to scaling and root planing (SRP) in deep probing depth sites. However, there are currently few randomized clinical studies confirming its effectiveness. The objective of this study was to assess whether SRP with minocycline impacted this patient group.
Materials and Methods: Nineteen patients with 2 pockets ≥ 5mm deep at contralateral sites were recruited and randomized into the test group (SRP+minocycline, 28 sites) and control group (SRP alone, 28 sites). Clinical parameters were collected at baseline, and at 30, and 90 days post-treatment.
Results: All clinical parameters improved from baseline in both groups, with no significant difference observed between the groups at any time point. The relative attachment level (RAL) significantly decreased from baseline to day 30 and day 90 in the test group, but significantly decreased only from baseline to day 30 in the control group. Moreover, the percentage of bleeding on probing sites was significantly improved in both groups from baseline to day 30.
Conclusion: The results from this study demonstrate that there was no significant difference in the clinical parameters on single-rooted teeth with moderate deep pockets in previously treated periodontitis patients over a three-month period between the SRP+minocycline and SRP alone groups.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Brown LJ, Johns BA, Wall TP. The economics of periodontal diseases. Periodontol. 2000 2002;29:223-234. doi: 10.1034/j.1600-0757.2002.290111.x.
Rabbani GM, Ash MM Jr, Caffesse RG. The effectiveness of subgingival scaling and root planing in calculus removal. J Periodontol. 1981 Mar;52(3):119–123. doi: 10.1902/jop.1981.52.3.119.
Gellin RG, Miller MC, Javed T, Engler WO, Mishkin DJ. The effectiveness of the Titan-S sonic scaler versus curettes in the removal of subgingival calculus. A human surgical evaluation. J Periodontol. 1986 Nov;57(11):672–680. doi: 10.1902/jop.1986.57.11.672.
Haffajee AD, Cugini MA, Dibart S, Smith C, Kent RL Jr, Socransky SS. The effect of SRP on the clinical and microbiological parameters of periodontal diseases. J Clin Periodontol. 1997 May;24(5):324-334. doi: 10.1111/j.1600-051x.1997.tb00765.x.
Mombelli A, Schmid B, Rutar A, Lang NP. Persistence patterns of Porphyromonas gingivalis, Prevotella intermedia/ nigrescens, and Actinobacillus actinomycetemcomitans after mechanical therapy of periodontal disease. J Periodontol. 2000 Jan;71(1):14–21. doi: 10.1902/jop.2000.71.1.14.
Giuliana G, Ammatuna P, Pizza G, Capone F, D'Angelo M. Occurrence of invading bacteria in radicular dentin of periodontally diseased teeth: microbiological findings. J Clin Periodontol. 1997 Jul;24(7):478-485. doi: 10.1111/j.1600-051x.1997.tb00215.x.
Calciolari E, Ercal P, Dourou M, Akcali A, Tagliaferri S, Donos N. The efficacy of adjunctive periodontal therapies during supportive periodontal care in patients with residual pockets. A systematic review and meta-analysis. J Periodontal Res. 2022 Aug;57(4):671-689. doi: 10.1111/jre.13001.
Bonito AJ, Lux L, Lohr KN. Impact of local adjuncts to scaling and root planing in periodontal disease therapy: a systematic review. J Periodontol. 2005 Aug;76(8):1227-1236. doi: 10.1902/jop.2005.76.8.1227.
Axelsson P, Lindhe J. The significance of maintenance care in the treatment of periodontal disease. J Clin Periodontol. 1981 Aug;8(4):281–294. doi: 10.1111/j.1600-051x.1981.tb02039.x.
Anderson GB, Palmer JA, Bye FL, Smith BA, Caffesse RG. Effectiveness of subgingival scaling and root planing: single versus multiple episodes of instrumentation. J Periodontol. 1996 Apr;67(4):367- 373. doi: 10.1902/jop.1996.67.4.367.
Jenkins WM, Said SH, Radvar M, Kinane DF. Effect of subgingival scaling during supportive therapy. J Clin Periodontol. 2000 Aug;27(8):590- 596. doi: 10.1034/j.1600-051x.2000.027008590.x.
Claffey N, Nylund K, Kiger R, Garrett S, Egelberg J. Diagnostic predictability of scores of plaque, bleeding, suppuration and probing depth for probing attachment loss. 3 1/2 years of observation following initial periodontal therapy. J Clin Periodontol. 1990 Feb; 17(2):108-114. doi: 10.1111/j.1600-051x.1990.tb01071.x
Manresa C, Sanz- Miralles EC, Twigg J, Bravo M. Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis. Cochrane Database Syst Rev. 2018 Jan;1(1):CD009376. doi: 10.1002/14651858.CD009376.pub2.
McColl E, Patel K, Dahlen G, Tonetti M, Graziani F, Suvan J, et al. Supportive periodontal therapy using mechanical instrumentation or 2% minocycline gel: a 12 month randomized, controlled, single masked pilot study. J Clin Periodontol. 2006 Feb;33(2):141-150.
Doyle DJ, Hendrix JM, Garmon EH. American Society of Anesthesiologists Classification. [Updated 2022 Dec 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441940/
Stelzel M, Florès‐de‐Jacoby L. Topical metronidazole application compared with subgingival scaling. A clinical and microbiological study on recall patients. J Clin Periodontol. 1996 Jan;23(1):24-29. doi: 10.1111/j.1600-051x.1996.tb00500.x.
O'Leary TJ, Drake RB, Naylor JE. The Plaque Control Record. J Periodontol. 1972 Jan;43(1):38. doi: 10.1902/jop.1972.43.1.38.
Löe H, Silness J. Periodontal Disease in Pregnancy I. Prevalence and Severity. Acta Odontol Scand. 1963 Dec;21(6):533–551. doi: 10.3109/00016356309011240.
Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J. 1975 Dec;25(4):229-235.
Kinane DF, Radvar M. A six-month comparison of three periodontal local antimicrobial therapies in persistent periodontal pockets. J Periodontol. 1999 Jan;70(1):1-7. doi: 10.1902/jop.1999.70.1.1.
Killeen AC, Harn JA, Erickson LM, Yu F, Reinhardt RA. Local Minocycline Effect on Inflammation and Clinical Attachment During Periodontal Maintenance: Randomized Clinical Trial. J Periodontol. 2016 Oct;87(10):1149-1157.
Greenstein G, Lamster I. Bacterial transmission in periodontal diseases: a critical review. J Periodontol. 1997 May;68(5):421-431. doi: 10.1902/jop.1997.68.5.421.
McNabb H, Mombelli A, Lang NP. Supragingival cleaning 3 times a week. The microbiological effects in moderately deep pockets. J Clin Periodontol. 1992 May;19(5):348–356. doi: 10.1111/j.1600-051x.1992.tb00658.x.
Goodson JM, Gunsolley JC, Grossi SG, Bland PS, Otomo-Corgel J, Doherty F, et al. Minocycline HCl microspheres reduce red-complex bacteria in periodontal disease therapy. J Periodontol. 2007 Aug;78(8):1568-1579. doi: 10.1902/jop.2007.060488.
Williams RC, Paquette DW, Offenbacher S, Adams DF, Armitage GC, Bray K, et al. Treatment of periodontitis by local administration of minocycline microspheres: a controlled trial. J Periodontol. 2001 Nov;72(11):1535-1544. doi: 10.1902/jop.2001.72.11.1535.
Drisko CL, Cobb CM, Killoy WJ, Michalowicz BS, Pihlstrom BL, Lowenguth RA, et al. Evaluation of periodontal treatments using controlled-release tetracycline fibers: clinical response. J Periodontol. 1995 Aug;66(8):692-699. doi: 10.1902/jop.1995.66.8.692.
Becker W. Tooth loss significantly reduced with non-surgical therapy. J Periodontol. 2000 May; 71(5):845. doi: 10.1902/jop.2000.71.5.845.
Kaldahl WB, Kalkwarf KL, Patil KD. A review of longitudinal studies that compared periodontal therapies. J Periodontol. 1993 Apr;64(4):243-253. doi: 10.1902/jop.1993.64.4.243.
Claffey N, Kelly A, Bergquist J, Egelberg J. Patterns of attachment loss in advanced periodontitis patients monitored following initial periodontal treatment. J Clin Periodontol. 1996 Jun; 23(6):523-531. doi: 10.1111/j.1600-051x.1996.tb01820.x.
Timmerman MF, van der Weijden GA, van Steenbergen TJ, Mantel MS, de Graaff J, van der Velden U. Evaluation of the long-term efficacy and safety of locally-applied minocycline in adult periodontitis patients. J Clin Periodontol. 1996 Aug;23(8):707–716. doi: 10.1111/j.1600-051x.1996.tb00599.x.
Sato K, Yoneyama T, Okamoto H, Dahlén G, Lindhe J. The effect of subgingival debridement on periodontal disease parameters and the subgingival microbiota. J Clin Periodontol. 1993 May;20(5):359–365. doi: 10.1111/j.1600-051x.1993.tb00373.x.