Clinical effect of 2% minocycline gel as an adjunct to scaling and root planing on single-rooted teeth in supportive periodontal therapy

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Pinyada Intharasaen
Yosvimol Kuphasuk
Pirasut Rodanant


Objective: In supportive periodontitis patients, local minocycline gel is used as an adjunct to scaling and root planing (SRP) in deep probing depth sites. However, there are currently few randomized clinical studies confirming its effectiveness. The objective of this study was to assess whether SRP with minocycline impacted this patient group.

Materials and Methods: Nineteen patients with 2 pockets ≥ 5mm deep at contralateral sites were recruited and randomized into the test group (SRP+minocycline, 28 sites) and control group (SRP alone, 28 sites). Clinical parameters were collected at baseline, and at 30, and 90 days post-treatment.

Results: All clinical parameters improved from baseline in both groups, with no significant difference observed between the groups at any time point. The relative attachment level (RAL) significantly decreased from baseline to day 30 and day 90 in the test group, but significantly decreased only from baseline to day 30 in the control group. Moreover, the percentage of bleeding on probing sites was significantly improved in both groups from baseline to day 30.

Conclusion: The results from this study demonstrate that there was no significant difference in the clinical parameters on single-rooted teeth with moderate deep pockets in previously treated periodontitis patients over a three-month period between the SRP+minocycline and SRP alone groups.


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Intharasaen P, Kuphasuk Y, Rodanant P. Clinical effect of 2% minocycline gel as an adjunct to scaling and root planing on single-rooted teeth in supportive periodontal therapy. M Dent J [Internet]. 2023 Aug. 24 [cited 2023 Dec. 5];43(2):63-72. Available from:
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