Effect of self-assembling peptide with fluoride on remineralization of primary teeth: An in vitro study.
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Abstract
Objectives: This study aimed to assess the remineralizing potential of a self-assembling peptide with fluoride (SAPF) on primary teeth compared to fluoride varnish and no treatment (control).
Materials and Methods: Thirty sound primary incisors were used, and surface microhardness (SMH) was measured before and after creating artificial enamel caries. The teeth were divided into three groups: SAPF, fluoride varnish (F), and control. After treatment and pH-cycling, SMH values were examined, and the percentage recovery of SMH (%SMHR) was calculated.
Results: SMH values after pH-cycling were significantly higher in the SAPF group (180.09±7.47 VHN) and F group (186.85±10.94) compared to the control group (117.45±8.17VHN) (p<0.001), but there were no significant differences between the SAPF and F groups (p=0.313). The %SMHR increased significantly in both SAPF (21.93±4.89%) and F group (25.75±10.14%) compared to the control group (-9.93±6.86%) (p<0.001).
Conclusions: The self-assembling peptide with fluoride demonstrated efficacy in remineralizing primary teeth comparable to fluoride varnish in vitro. This suggests its potential as an alternative treatment for dental caries.
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