Associated Severity of Common Clinical Symptoms with Anxiety and Depression among Patients with Advanced Cancer

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Pornpimon Lertpanit
Patthranit Methipisit
Vatcharin Wuthironarith
Suparat Panpoklang
Ampaporn Namvongprom


Objective: This descriptive cross-sectional study aimed to examine anxiety, depression and symptom severity of patients with advanced cancer. Methods: Sample were patients with advanced cancer. A purposive sample of 428 patients was recruited for this study. Data were collected by using Patient Information Sheet and Edmonton Symptom Assessment Scale (ESAS). Data were analyzed by using descriptive statistics and Spearman Rank Correlation. Results: The findings revealed that the overall average scores of anxiety and depression were at a low levels M = 3.41 (SD = 2.36) and M = 3.64 (SD = 2.25), respectively It was found that 41.58% and 36.22% of patients perceived anxiety and depression at moderate-to-high levels which required transferring to the palliative care team. Top three reported symptoms severity were poor appetite, not getting well and fatigue. It was found that severity of symptoms were significantly positive correlated with
anxiety and depression (p < .05), except nausea. Depression of the groups of patients between those received the palliative treatment (chemotherapy and radiotherapy) and the symptomatic treatment (general standard); as well as the In-patient the between and the outpatient department patients were not statistically different. For anxiety, significant difference between the palliative and symptomatic treatment groups was found. However, there was non-significant difference between the In-Patient Department (IPD) and Out-Patient Department (OPD) groups. Discussion: These findings underscore the need for routine screening of symptom were severity because these symptoms were associated with anxiety and depression in palliative care setting.


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Lertpanit, P. ., Methipisit, P. ., Wuthironarith, V. ., Panpoklang, S. ., & Namvongprom, A. . (2021). Associated Severity of Common Clinical Symptoms with Anxiety and Depression among Patients with Advanced Cancer. Journal of Research in Nursing-Midwifery and Health Sciences, 41(3), 1–12. Retrieved from
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