Factors associated with death during tuberculosis treatment among new patients with pulmonary tuberculosis in Health Region 10th

Abstract

This study aimed to determine the factors associated with death during Tuberculosis (TB) treatment in the Health Region 10^th. A retrospective study among new pulmonary TB patients aged 15 years and above who registered in the National Tuberculosis Information Program (NTIP) between 1 October 2017 to 30 September 2019, excluded patients who were ongoing treatment, the final diagnosis was changed to another disease than TB, the registration was changed to drug-resistant TB patients, and causes of death from accident or suicide. A total of 11,466 new pulmonary TB patients enrolled in this study, 10,421 (90.89%) survived and 1,045 (9.11%) died, 71% died within the first 2 months of TB treatment. Results from multiple logistic regression showed factors associated with death during TB treatment were age 60 years and above (OR_adj 3.52; 95%CI 3.02-4.11), patients with cancer (OR_adj 4.52; 95%CI 2.40-8.54), chronic kidney disease (OR_adj 3.34; 95%CI 2.52-4.42), liver disease (OR_adj 3.57; 95%CI 1.39-9.15), hypertension (OR_adj 1.28; 95%CI 1.01-1.61), HIV-infected (OR_adj 5.69; 95%CI 4.44-7.28), and patients with unknown HIV status (OR_adj 2.10; 95%CI 1.73-2.56). Therefore, continuity of the implementation of TB active case finding in the elderly person, people with underlying disease and HIV-infected to early diagnosis and treatment to reduce the severity and the TB mortality rate.