Effectiveness of trivalent inactivated influenza vaccine among older adults in Nakhon Phanom province: a two-year prospective cohort study
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ประสิทธิผลของวัคซีน, ไข้หวัดใหญ่, ผู้สูงอายุAbstract
This two-year prospective cohort study to measure the effectiveness of trivalent inactivated influenza vaccine (IIV3) to prevent laboratory-confirmed influenza among adults aged ≥ 65 years during 2015-16 and 2016-17 influenza seasons. In 2015, we enrolled a cohort of 3,220 participants. Trained health volunteers collected baseline data and followed participants for two years with weekly surveillance for new or worsened cough with self-collection of nasal swabs. Vaccine effectiveness (VE) was estimated as 100% × (1- rate ratio of rRT-PCR -confirmed influenza) among vaccinated versus unvaccinated participants. Propensity score stratification was used to reduce differences between vaccinated and unvaccinated participants associated with access to and receipt of IIV3. During 2015-16 and 2016-17, 1,666 (52%) and 1,498 (48%) participants received IIV3, respectively. The overall incidence of influenza during the two seasons was 14.3/1000 person-years among vaccinated participants and 20.2/1000 person-years among unvaccinated participants. VE was -4% (95% confidence interval [CI], -83%–40%) during 2015-16, and 50% (95% CI, 12%–71%) during 2016-17. Of all three influenza subtypes in both years, significant protection was observed only against Influenza A/H3N2 during 2016-17 (VE, 49%; 95% CI, 3%–73%). In Summary IIV3 was moderately effective against laboratory-confirmed influenza among older adults in Nakhon Phanom.
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บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของ สำนักงานป้องกันควบคุมโรคที่ 10 จังหวัดอุบลราชธานี
ข้อความที่ปรากฏในบทความแต่ละเรื่องในวารสารวิชาการเล่มนี้เป็นความคิดเห็นส่วนตัวของผู้เขียนแต่ละท่านไม่เกี่ยวข้องกับสำนักงานป้องกันควบคุมโรคที่ 10 จังหวัดอุบลราชธานีและบุคลากรท่านอื่นๆในสำนักงานฯ แต่อย่างใด ความรับผิดชอบองค์ประกอบทั้งหมดของบทความแต่ละเรื่องเป็นของผู้เขียนแต่ละท่าน หากมีความผิดพลาดใดๆ ผู้เขียนแต่ละท่านจะรับผิดชอบบทความของตนเองแต่ผู้เดียว
