Incidence and Factors Associated to Adverse Events Following Immunization for COVID-19 in People who Received Vaccination at Warinchamrab District, Ubonratchathani Province

Abstract

The COIVID-19 vaccines were newly and urgently developed. Lack of data of adverse events when it is widely used. The objective of this study was to study the incidence and factors associated with Adverse Events Following Immunization (AEFI) for COVID-19 in people who received vaccination at Warinchamrab District, Ubonratchathani Province between April 6, 2021, and September 30, 2022. Data were collected from hospital information system, MOPH Immunization Center and AEFI-DDC Surveillance System. The results of the study found that among people who received a total of 141,143 doses of the COVID-19 vaccine, a total of 8,094 reports of adverse events (5.7%) were found, of which 8,073 reports (99.7%) were not serious, found in females more than males (aOR= 2.22 95%CI: 2.07-2.34). People over 60 years of age are less common than other age groups (aOR= 0.63 95%CI: 0.52-0.74). Meanwhile, healthcare personnel and outbreak control offices reported adverse events more frequently than other groups (aOR=8.73 95%CI: 7.59-9.88 and aOR=9.65 95%CI: 8.23-10.91 respectively). The most adverse events reported was Moderna (1,186.6 report per ten thousand doses) and 21 (0.3 percent) reported serious COVID-19 vaccine events, including stroke (11 reports), myocardial infarction (2 reports), congestive heart failure (1 report), and high blood pressure crisis (1 report), acute respiratory distress syndrome (1 report), anaphylaxis (1 report), encephalitis (1 report), and death (2 reports). In conclusion, the COVID-19 vaccine, which is important in disease prevention, has frequently found adverse events after immunization. But almost all of them are not serious. Overall, it is safe. However, healthcare personnel and people should be aware of possible adverse events.