Prasachandaeng Remedy

Main Article Content

Panisara Krongmongkol

Abstract

Prasachandaeng remedy is one of the traditional herbal formulations included in the Thailand National List of Essential Medicines. It consists of twelve medicinal herbs and is traditionally used to relieve fever (toxic fever) and alleviate internal heat and thirst. In addition, pharmacological studies have been conducted on its antipyretic and anti-inflammatory activities through the inhibition of nitric oxide (NO), as well as its antibacterial activity against both Gram-positive and Gram-negative bacteria using a 95% ethanol extract of the Prasachandaeng formulation. Furthermore, its safety regarding liver function has been investigated using Prasachandaeng powder.

Article Details

Section
Interesting Drugs

References

Faculty of Pharmaceutical Sciences, Ubon Rtachathani University. Red sanders [Internet]. 2010 [cited 2025 Oct 21]. Available from: https://phar.ubu.ac.th/herb-DetailPhargarden/34

Fan JY, Yi T, Sze-To CM, Zhu L, Peng WL, Zhang YZ, et al. A systematic review of the botanical, phytochemical and pharmacological profile of Dracaena cochinchinensis, a plant source of the ethnomedicine "dragon's blood". Molecules 2014;19:10650-69.

Walailak Botanic Park. Nutmeg [Internet]. 2025 [cited 2025 Oct 24]. Available from: https://botany.wu.ac.th/?page_id=15471

Ashokkumar K, Simal-Gandara J, Murugan M, Dhanya MK, Pandian A. Nutmeg (Myristica fragrans Houtt.) essential oil: a review on its composition, biological, and pharmacological activities. Phytother Res 2022;36:2839-51.

Forest Herbarium. Plum mango [Internet]. 2025 [cited 2025 Oct 24]. Available from: https://botany.dnp.go.th/herb_qr/index.html?code=Bou_opp

Ha KN, Nguyen TV, Mai DT, Tran NM, Nguyen NH, Vo GV, et al. Alpha-glucosidase inhibitors from Nervilia concolor, Tecoma stans, and Bouea macrophylla. Saudi J Biol Sci 2022;29:1029-42.

On-Nom N, Thangsiri S, Inthachat W, Temviriyanukul P, Trisonthi P, Chupeerach C, et al. Phenolic profiles and in vitro biochemical properties of Thai herb ingredients for chronic diseases prevention. Sci Rep [Internet]. 2023 [cited 2026 Jan 4];13(1):21690. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10709644/pdf/41598_2023_Article_49074.pdf

Ayurvedic College. Traditional Thai medical textbooks (medicine welfare conservation) Vol.1. Bangkok: Foundation for the Restoration and Promotion of Traditional Thai Medicine;2007.

Panthong S. Antibacterial activity against foodborne pathogen and anti-inflammatory activity of Caesalpinia sappan heartwood. Journal of Thai Traditional & Alternative Medicine. 2022;20:597-604.

Faculty of Pharmaceutical Sciences, Ubon Rtachathani University. Key lime [Internet]. 2013 [cited 2025 Oct 24]. Available from: https://phar.ubu.ac.th/herb-DetailThaicrudedrug/105

Indriyani NN, Anshori JA, Permadi N, Nurjanah S, Julaeha E. Bioactive components and their activities from different parts of citrus aurantifolia (Christm.) swingle for food development. Foods [Internet]. 2023 [cited 2025 Oct 24];12(10):2036. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10217416/pdf/foods-12-02036.pdf

Faculty of Pharmaceutical Sciences, Ubon Rtachathani University. Scleropyrum pentandrum [Internet]. 2013 [cited 2025 Oct 25]. Available from: https://phar.ubu.ac.th/herb-DetailPhargarden/231

Trung BV, Anh DH, Viet PH, Kiem PV. Hepatoprotective and antioxidant activities of phenolic compounds from Heliciopsis terminalis. Natural Product Communications [Internet]. 2023 [cited 2026 Jan 4];18(5). Available from: https://journals.sagepub.com/doi/epub/10.1177/1934578X231174993

Saechan C, Nguyen UH, Wang Z, Sugimoto S, Yamano Y, Matsunami K, et al. Potency of bisresorcinol from Heliciopsis terminalis on skin aging: in vitro bioactivities and molecular interactions. PeerJ [Internet]. 2021 [cited 2026 Jan 4];9:e11618. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8231342/pdf/peerj-09-11618.pdf

Wang SY, Zhao H, Xu HT, Han XD, Wu YS, Xu FF, et al. Kaempferia galanga L.: progresses in phytochemistry, pharmacology, toxicology and ethnomedicinal uses. Front Pharmacol [Internet]. 2021 [cited 2026 Jan 4];12:675350. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8560697/pdf/fphar-12-675350.pdf

Kong Q, Niu Y, Feng H, Yu X, Wang B, Liu X, et al. Ligusticum chuanxiong hort.: a review of its phytochemistry, pharmacology, and toxicology. J Pharm Pharmacol 2024;76:1404-30.

Tan L, Liao FF, Long LZ, Ma XC, Peng YX, Lu JM, et al. Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis. Front Public Health [Internet]. 2023 [cited 2026 Jan 4];11:1144404. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10267315/pdf/fpubh-11-1144404.pdf

Faculty of Pharmaceutical Sciences, Ubon Rtachathani University. Mammea siamensis [Internet]. 2014 [cited 2025 Oct 24]. Available from: https://phar.ubu.ac.th/herb-DetailThaicrudedrug/165

Suriyaprom S, Cheepchirasuk N, Ngamsaard P, Intachaisri V, Inta A, Tragoolpua Y. Thai medicinal flowers as natural antioxidants and antibacterial agents against pathogenic enteric bacteria: a comparative study of Mesua ferrea, Mammea siamensis, and Clitoria ternatea. Antibiotics (Basel) [Internet]. 2025 [cited 2026 Jan 4];14(10):1038. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC12561062/pdf/antibiotics-14-01038.pdf

Mokmued K, Ruangnoo S, Itharat A. Anti-inflammatory of the ethanolic extract of Thai traditional post-partum remedy (Sa-Tri-Lhang-Klod) and plant ingredients. Thammasat Medical Journal 2017;17:557-64.

Adib AM, Yunos NM, Jin CB. Anti-cancer, antimicrobial, and antioxidative potentials of Mesua ferrea L. and its phytochemical constituents: a review. The Asian Journal of Pharmacognosy 2019;3(3):5-19.

Thonmak K, Janpat T, Chandang R, Marde W, Noipha K. Preliminary phytochemical study and antioxidant activity of five flowers remedy. Journal of Traditional Thai Medical Research 2021;7(2):61-74.

National Drug System Development Committee. The Thai national list of essential herbal medicine [Internet]. 2023 [cited 2024 Dec 18]. Available from: https://ratchakitcha.soc.go.th/documents/140D130S0000000004500.pdf

Prommee N, Itharat A, Panthong S, Makchuchit S, Ooraikul B. Ethnopharmacological analysis from Thai traditional medicine called prasachandaeng remedy as a potential antipyretic drug. J Ethnopharmacol [Internet]. 2021 [cited 2025 Oct 25];268:113520. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0378874120334061?via%3Dihub

Sangphum A. Biological activities of Thai traditional remedy called Prasachandaeng and its plant ingredients [Thesis]. Bangkok: Thammasat University; 2016.

Varichanan P, Siriwan D, Dueramea S. Antibacterial activity of extracts from Chanthaharuethai and Prasachandaeng formulations. YRU Journal of Science and Technology 2023;8(2):29-37.

Prommee N, Itharat A, Thisayakorn K, Sukkasem K, Inprasit J, Tasanarong A, et al. Investigations of the antipyretic effect and safety of Prasachandaeng, a traditional remedy from Thailand national list of essential medicines. Biomed Pharmacother [Internet]. 2022 [cited 2025 Oct 25];147:112673. Available from: https://www.sciencedirect.com/science/article/pii/S0753332222000610?via%3Dihub