Clinical manifestation and treatment outcome of patients with both HIV and tuberculosis infection in HIV/AIDS clinic Prapokklap hospital.

Abstract

Background : Tuberculosis (TB) and HIV infection were common and were serious problems of health in Thailand. Co-infection of TB and HIV caused more problems of treatment and care.

Objective : For study the clinical manifestation and result of treatment in patients co-infected with both HIV and TB.

Methods : A retrospective study of HIV patients with TB who received Highly active antiretroviral therapy (HAART) at least 6 months in HIV/AIDS clinic,Prapoklao hospital, during 1 October 2005 – 30 August 2009. Clinical manifestation of TB and treatment outcome of HAART was reviewed.

Results : Two hundred and thirteen patients from 580 patients (36.7 Percent) had coinfection of TB and HIV. Common clinical presentation of TB was prolong fever 64.3 Percent, body weight loss 60 Percent and chronic cough 38.3 Percent. Diagnosis of pulmonary TB was 109 times, extrapulmonary TB was 103 times and both pulmonary and extrapulmonary TB was 23 times.The most common site of extrapulmonary TB was lymph node, occurred 84 times. The mean duration of received HAART was 3 years and virological response was 89 Percent.

Conclusions : Patient with HIV and tuberculosis co-infection may be subclinical or oligosymptomatic presentation. HIV care team should be consider of both infection and treated with antiTB and HAART together.