Helicobacter pylori infection in Chronic dyspepsia patients Prapokklao Hospital.
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Abstract
Back ground : H. pylori is a major cause of gastritis & peptic ulcer disease (PUD) and has been implicated in development of gastric malignancy. The prevalence of H. Pylori, a
worldwide infection, varies greatly among countries, population groups & environment. H. pylori are highly prevalence in the developing country.
Objective : To studied the incidence of H. pylori infection among chronic dyspepsia patients in Prapokkao hospital and report H. pylori associated with different histopathology and upper gastrointestinal endoscopy (UGIE) findings
Methods : A prospective study was perform in devision of Gastroenterology and Hepatology,Prapokklao hospital since july 1999 to october 2007. Seven hundred and twenty four chronic dyspepsia patients (300 male, 424 female, mean age 51.0 years SD =17.27) consecutively underwent upper gastro intestinal endoscopy. Multiple gastric antral biopsy samples were taken from all patients for Rapid urease test and histologic examination (97.2 percent satisfactory samples), patients were considered H. pylori infection if any or both test were positive.
Result : Two hundred and forty patients of 724 chronic dyspepsia patients (33.1 percent) were H. pylori-infected. H. pylori positivity was significantly more frequent in patient with peptic ulcer disease (PUD) than in those with non ulcer dyspepsia (NUD) (p=0.02) The frequency of H. pylori infection among those with endoscopic diagnosis of gastritis, gastric ulcer, duodenal ulcer, gastric tumor and normal study was 28.4 percent (82/289), 40.5 percent (30/74), 50 percent (9/18), 12.5 percent (1/8) and 36 percent (80/222) respectively. H. pylori positivity was associated with chronic nonspecific gastritis and chronic active gastritis histology
were 30.6 percent (152/497) and 90.1 percent (73/81) respectively (p<0.001)
Conclusion : The prevalence of H. pylori infection with chronic dyspepsia patients was still high and had correlation to GU.,DU.,PUD and histologic changed especially chronic active gastritis.