Hepatitis B: real - life practice in Prapokklao Hospital

Abstract

Background : Previous HBV- related data was based on clinical trial study. Since results
cannot always be extrapolated to daily practice. Real life practice study
made data available to complement data from clinical trial study.
Objective : To review the initial evaluation, diagnosis, follow- up, treatment option,
treatment outcome and complication of HBV-infected patient. And to put
data from real life practice into perspective.
Method : We review all cases of HBV-infected patient in liver clinic at Prapokklao
Hospital from September 2006 to November 2011.
Results : A total of 210 HBV-infected patients, 56 patients (26.7 percent) were HBeAg
positive,154 patients (73.3 percent) were HBeAg negative, 65 patients (30.9
percent) had pre-existing cirrhosis. Initial HBV-DNA level were performed
in 147 patients (70 percent).There were 115 patients (63 percent) required
treatment. Lamivudine (LAM) was preffered in most cases. HBe Ag seroconversion
achieved in 9 patients (39 percent) with HBe Ag positive and 34
patients (47.6 percent) with HBeAg negative can achieve viral suppression after 1- year LAM therapy. In patients with decompensated cirrhosis, there
were significantly improvement in liver function and Child Pugh score (CPS)
after treatment with nucleos(t)ide analogues. Elevent patients (5.2 percent)
die of liver- related condition.
Conclusion : Clinical outcomes in this real-life practice study were similar to previous
clinical trials.