Prostate Specific Antigen Level in Thai Male Adults' Semen
Keywords:
Age, Enzyme-linked immunosorbent assay, Prostate specific antigen, Semen, ThaiAbstract
Objectives: The purposes of this study were to determine the seminal PSA level in Thai male and to determine its association with the age of subjects and with the quantity of ejaculates.
Method: This study was an experimental research. Semen samples were obtained from the volunteers who signed an informed consent document approved by the Institution Review Board at the Faculty of Medicine Siriraj Hospital, Mahidol University. All voluntees were Thai healthy male adults aged 20 - 60 years without any recent acute illness/fever and were strictly asked not to have sexual intercourse/self-masturbation at least 5 days prior to semen collection. All samples were stored at -80 ํC shortly after being secreted from the volunteers' body until analyzed. The earlier reported ELISA protocol was used to perform the study.
Results: The semen samples were obtained from 17 volunteers with mean age 32.9 10.2 years (22 - 55 years) and mean semen volume 2.5
0.6 ml (1.5 - 3.5 ml). The seminal PSA concentrations were in the range of 503,636 - 519,090 ng/ml with the mean value of 513,502
4,211 ng/ml. The seminal PSA level was associated with the subject's age in negative correlation (r = -0.547, P < 0.01).
Conclusions: The mean seminal PSA concentration in Thai male adults was reported here. From the styudy, it was found that the PSA levels were decreased when the subject's age were increased, and the PSA levels were increased when the quantities of ejaculated semen were increased. However, further studies with a larger sample size may be needed to confirm these results as to a preliminary study.
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