Disease-free Probability and Triple-Negative Breast Cancer

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Prakasit Chirappapha
Thongchai Sukarayothin
Yodying Wasuthit
Ronnarat Suvikapalornkul
Panuwat Lertsithichai
Youwanush Kongdan


Objective: To compare the probabilities of local recurrence and distant metastasis between women with triple-negative and non- triple negative breast cancers.

Methods: Medical and pathological records of breast cancer patients treated between the years 2002 and 2006 were reviewed.

Results: There were 256 patients with complete data on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) expression determinations. There were 54 patients (21%) with triple-negative (ER-, PR-, HER2 -) cancers. Triple-negative patients were more likely to have larger tumors with higher histologic grade. The median fallow-up time was 4 years. The probabilities of local and distant recurrence were similar between the two groups of patients. Only two factors were independently and significantly associated with overall recurrence: tumor stage and tumor size.

Conclusion: Triple-negative breast cancer did not have a higher risk for both local recurrence and distant metastasis when compared with non-triple negative cancer.

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How to Cite
Chirappapha, P., Sukarayothin, T., Wasuthit, Y., Suvikapalornkul, R., Lertsithichai, P., & Kongdan, Y. (2012). Disease-free Probability and Triple-Negative Breast Cancer. Ramathibodi Medical Journal, 35(1), 5–13. https://doi.org/10.33165/rmj.2012.35.1.117663
Original Articles


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