The Correlation Between Common Aeroallergen Sensitization and Quality of Life in Adult Chronic Rhinitis Patients

Nichapha Dechapaphapitak; Malinee Tongdee; Chamard Wongsa; Thanuchporn Kafaksom; Umaporn Udomsubpayakul; Wannada Laisuan

doi:10.14456/rmj.2018.40

Authors

Nichapha Dechapaphapitak Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Malinee Tongdee Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Chamard Wongsa Allergy center, Siriraj Piyamaharajkarun Hospital, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Thanuchporn Kafaksom Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Umaporn Udomsubpayakul Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Wannada Laisuan Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

DOI:

https://doi.org/10.14456/rmj.2018.40

Keywords:

Quality of life, Chronic rhinitis, Aeroallergen sensitization, Skin prick test, Allergic rhinitis, Non-allergic rhinitis

Abstract

Background: There is variation in clinical presentations of chronic rhinitis patients from mild to severe symptoms which affect the quality of life in different degrees.

Objective: To study the correlation among size, type of positive skin prick test to common aeroallergens, and other factors that affect the quality of life in chronic rhinitis patients.

Methods: A descriptive cross-sectional study in new patients who were diagnosed chronic rhinitis at adult allergy clinic, Ramathibodi Hospital, from August 2017 to December 2017. Quality of life, severity of clinical presentation, and skin prick test results of patients were collected

Results: Of 130 patients, 85 (65.4%) were female. Result showed that the type and size of aeroallergen sensitization gave a positive result, and has inverse correlation with quality of life in chronic rhinitis patients, but only mite (Der f) and cockroach (r = -0.283 to -0.234, P < 0.05) However, the severity of nasal (Total nasal symptom score, TNSS) and other symptoms (Total other symptom score, TOSS) were significantly difference between TNSS > 6, TNSS ≤ 6 and TOSS > 6, TOSS ≤ 6. The result showed that patients with TNSS > 6 and TOSS > 6 had significantly lower function in every aspects in a quality of life (P < 0.05) except quality of life about absenteeism (P = 0.16).

Conclusions: This study showed that type and size of positive skin prick test were not correlated to quality of life. However, severity of symptom were correlated with quality of life in chronic rhinitis patients.

References

Brown KR, Bernstein JA. Clinically relevant outcome measures of novel pharmacotherapy for nonallergic rhinitis. Curr Opin Allergy Clin Immunol. 2015;15(3):204-212. doi:10.1097/ACI.0000000000000166.

Bousquet J, Khaltaev N, Cruz AA, et al. Allergic rhinitis and its impact on asthma (ARIA) 2008. Allergy. 2008;63(Suppl 86):8-160. doi:10.1111/j.1398-9995.2007.01620.x.

Settipane RA. Complications of allergic rhinitis. Allergy Asthma Proc. 1999;20(4):209-213.

Skoner DP. Complications of allergic rhinitis. J Allergy Clin Immunol. 2000;105(6 Pt 2):S605-S609.

Bunnag C, Noona R, Prasungsit C. Factors associated with quality of life for the patients with limb ischemia. J Nurs Sci. 2011;29(2):27-36.

Sapsaprang S, Setabutr D, Kulalert P, Temboonnark P, Poachanukoon O. Evaluating the impact of allergic rhinitis on quality of life among Thai students. Int Forum Allergy Rhinol. 2015;5(9):801-807. doi:10.1002/alr.21540.

Dziekanski M, Marcelino TF. Quality of life in pediatric patients with allergic rhinitis treated at the Medical Clinic of Integrated Education - Unisul. Int Arch Otorhinolaryngol. 2017;21(4):371-376. doi:10.1055/s-0037-1599095.

Office of the Prime Minister (Thailand). The 12th National Economic and Social Development Plan (2017-2021). The National Economic and Social Development Board. 2017;65-74. https://www.nesdb.go.th/ewt_dl_link.php?nid=6422. Accessed May 1, 2018.

Leurmarnkul W, Meetam P. Properties testing of the retranslated SF-36 (Thai version). Thai J Pharm Sci. 2005;29(1-2):69-90.

Bunnag C, Leurmarnkul W, Jareoncharsri P, Tunsuriyawong P, Assanasen P, Pawankar R. Quality of life assessment in Thai patients with allergic rhinoconjunctivitis using the SF-36 questionnaire (Thai version). Rhinology. 2005;43(2):99-103.

Mosges R, König V, Koberlein J. The effectiveness of modern antihistamines for treatment of allergic rhinitis-an IPD meta-analysis of 140,853 patients. Allergol Int. 2013;62(2):215-222. doi:10.2332/allegrolint.12-OA-0486.

Cazzoletti L, Ferrari M, Olivieri M, et al. The gender, age and risk factor distribution differs in self-reported allergic and non-allergic rhinitis: a cross-sectional population-based study. Allergy Asthma Clin Immunol. 2015;11:36. doi:10.1186/s13223-015-0101-1.

Oncham S, Tongdee M, Dachaprapapitak N, Kafaksom T, Wongsa C, Laisuan W. Prevalence of aeroallergen sensitization from skin prick test in allergy clinic at Ramathibodi Hospital. Ramathibodi Medical Journal. 2018;41(2):9-15. doi:10.14456/rmj.2018.13

Wang XY, Ma TT, Wang XY, et al. Prevalence of pollen‐induced allergic rhinitis with high pollen exposure in grasslands of northern China. Allergy. 2018;73(6):1232-1243. doi:10.1111/all.13388.

Aydin S, Hardal U, Atli H. An analysis of skin prick test reactions in allergic rhinitis patients in Istanbul, Turkey. Asian Pac J Allergy Immunol. 2009;27(1):19-25.

Pumhirun P, Towiwat P, Mahakit P. Aeroallergen sensitivity of Thai patients with allergic rhinitis. Asian Pac J Allergy Immunol. 1997;15(4):183-185.

Jaruvongvanich V, Mongkolpathumrat P, Chantaphakul H, Klaewsongkram J. Extranasal symptoms of allergic rhinitis are difficult to treat and affect quality of life. Allergol Int. 2016;65(2):199-203. doi:10.1016/j.alit.2015.11.006.

Udaka T, Suzuki H, Kitamura T, et al. Relationships among nasal obstruction, daytime sleepiness, and quality of life. Laryngoscope. 2006;116(12):2129-2132. doi:10.1097/01.mlg.0000239111.24094.a3.

Hoehle LP, Speth MM, Phillips KM, et al. Association between symptoms of allergic rhinitis with decreased general health‐related quality of life. Am J Rhinol Allergy. 2017;31(4):235-239. doi:10.2500/ajra.2017.31.4444.

Roger A, Arcalá Campillo E, Torres MC, et al. Reduced work/academic performance and quality of life in patients with allergic rhinitis and impact of allergen immunotherapy. Allergy Asthma Clin Immunol. 2016;12:40. doi:10.1186/s13223-016-0146-9.

Ramakrishnan VR. Pharmacotherapy for nonallergic rhinitis. Medscape; 2017. https://emedicine.medscape.com/article/874171-overview. Accessed May 1, 2018.

Li L, Guan K. Effect on quality of life of the mixed house dust mite/weed pollen extract immunotherapy. Asia Pac Allergy. 2016;6(3):168-173. doi:10.5415/apallergy.2016.6.3.168.

Tatar EC, Sürenoğlu UA, Saylam G, Işık E, Ozdek A, Korkmaz H. Is there any correlation between the results of skin-prick test and the severity of symptoms in allergic rhinitis? Am J Rhinol Allergy. 2012;26(1):e37-e39. doi:10.2500/ajra.2012.26.3750.