Clinical Outcomes of Antibiotic Prophylaxis in Vaginal Delivery Women at Ramathibodi Hospital

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Sophaphan Ploungbunmee
Pornsri Disorntatiwat
Sommart Bumrungphuet
Nitaya Rotjananirankit


Background: The rate of antibiotic use of vaginal delivery women in Ramathibodi Hospital is higher than expected standard criteria. The obstetrician team has developed clinical practice guidelines for rational drug use in antibiotic prophylaxis in vaginal delivery women.

Objectives: To examine the relationships among the percentage of using antibiotic prophylaxis, the prevalence of rational drug use and the prevalence of the episiotomy wound infection rate in vaginal delivery women before and after using the clinical practice guidelines for antibiotic prophylaxis.

Methods: The sample consisted of 983 vaginal delivery women who did not in the practice guidelines and 914 joined in practice guidelines groups. The rate of antibiotic use and episiotomy wound infection were collected before and after using the clinical practice guidelines for antibiotic prophylaxis. Data were analyzed by chi-square statistics.

Results: The rate of antibiotic use in vaginal delivery women is significantly related to the use of the practice guidelines (P < .01), which is reduced from 25.43% to 9.85%. The prevalence of rational drug use increased from 12.40% to 34.44%. The prevalence of episiotomy wound infection of women vaginal birth before and after using the practice guidelines was not significantly different (P = .96). There was no episiotomy wound infection in both groups.

Conclusions: The clinical practice guidelines reduces antibiotic use in postpartum women without episiotomy wound infection and promotes rational drug use.

Article Details

How to Cite
Ploungbunmee, S., Disorntatiwat, P., Bumrungphuet, S., & Rotjananirankit, N. (2019). Clinical Outcomes of Antibiotic Prophylaxis in Vaginal Delivery Women at Ramathibodi Hospital. Ramathibodi Medical Journal, 42(3), 12 - 23.
Original Articles


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