Oxidative Stress in Pediatric Patients with Acute Lymphoblastic Leukemia
Keywords:
Oxidative stress, Acute lymphoblastic leukemia, Pediatric patients, Cancer, AntioxidantAbstract
Oxidative stress is associated with cancers via many mechanisms including lipid peroxidation and DNA damage. The interest in research on the role of free radicals in cancer pathogenesis is increasing. Acute lymphoblastic leukemia (ALL), the most common childhood cancer, is the primary cause of cancer-related mortality in children. Many components given to treat leukemia are associated with free radical production. In addition, the properties of antioxidant compounds for protection and alleviation of side effects of chemotherapy have been reported. However, there are a few reports on oxidative stress and antioxidant status in children with ALL. Therefore, we reviewed this topic for scientific knowledge and future research.
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