Prevalence, Types, and Factors of HPV Infection Among Women With Abnormal Cervical Cytology Screening at Ramathibodi Hospital
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Abstract
Background: Cervical cancer is the second leading cancer among Thai women. Human papillomavirus (HPV) is the most common cause of cervical cancer. HPV16 and HPV18 are the most prevalence types in women with cervical cancer.
Objectives: To study the prevalence and types of HPV infection and its associated risk factors among women with abnormal cervical cytology screening.
Methods: This cross-sectional study purposively recruited 376 women who had abnormal cervical cytology screening by liquid-based cytology at the outpatient clinic, Ramathibodi Hospital from August 2015 until March 2016. HPV genotyping was done by the polymerase chain reaction (PCR). Analysis of the personal characteristics was done using descriptive statistics.
Results: The prevalence of HPV infection was 41.5%. Among them, a single infection was found in 78.8% of women. The most common genotypes were HPV16 (8.5%) and HPV52 (7.7%). But HPV18 was found in only 1.9%. The characteristic which was significantly associated with HPV infection was age, nulliparity, and high-graded dysplasia (P < .05).
Conclusions: High prevalence rate of HPV infection was found among women with abnormal cytology. High-risk HPV prevalence and type distribution may be useful for public health authorities in assessing the cervical screening program.
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References
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. doi:10.3322/caac.21492
Walboomers JM, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189(1):12-19. doi:10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F
Chelimo C, Wouldes TA, Cameron LD, Elwood JM. Risk factors for and prevention of human papillomaviruses (HPV), genital warts and cervical cancer. J Infect. 2013;66(3):207-217. doi:10.1016/j.jinf.2012.10.02
Muñoz N, Bosch FX, de Sanjosé S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348(6):518-527. doi:10.1056/NEJMoa021641
Bulkmans NW, Berkhof J, Bulk S, et al. High-risk HPV type-specific clearance rates in cervical screening. Br J Cancer. 2007;96(9):1419-1424. doi:10.1038/sj.bjc.6603653
Stanley M. Pathology and epidemiology of HPV infection in females. Gynecol Oncol. 2010;117(2Suppl):S5-S10. doi:10.1016/j.ygyno.2010.01.024
Sukvirach S, Smith JS, Tunsakul S, et al. Population-based human papillomavirus prevalence in Lampang and Songkla, Thailand. J Infect Dis. 2003;187(8):1246-1256. doi:10.1086/373901
Sun ZR, Ji YH, Zhou WQ, Zhang SL, Jiang WG, Ruan Q. Characteristics of HPV prevalence among women in Liaoning province, China. Int J Gynaecol Obstet. 2010;109(2):105-109. doi:10.1016/j.ijgo.2009.11.02
Laowahutanont P, Karalak A, Wongsena M, et al. Prevalence of high risk human papillomavirus infection with different cervical cytological features among women undergoing health examination at the National Cancer Institute, Thailand. Asian Pac J Cancer Prev. 2014;15(14):5879-5882. doi:10.7314/apjcp.2014.15.14.5879
Roset Bahmanyar E, Paavonen J, Naud P, et al. Prevalence and risk factors for cervical HPV infection and abnormalities in young adult women at enrolment in the multinational PATRICIA trial. Gynecol Oncol. 2012;127(3):440-450. doi:10.1016/j.ygyno.2012.08.033
Natphopsuk S, Settheetham-Ishida W, Pientong C, et al. Human papillomavirus genotypes and cervical cancer in northeast Thailand. Asian Pac J Cancer Prev. 2013;14(11):6961-6964. doi:10.7314/apjcp.2013.14.11.6961
Marks MA, Gupta S, Liaw KL, et al. Prevalence and correlates of HPV among women attending family-planning clinics in Thailand. BMC Infect Dis. 2015;15:159. doi:10.1186/s12879-015-0886-z
Kantathavorn N, Mahidol C, Sritana N, et al. Genotypic distribution of human papillomavirus (HPV) and cervical cytology findings in 5906 Thai women undergoing cervical cancer screening programs. Infect Agent Cancer. 2015;10:7. doi:10.1186/s13027-015-0001-5
Souho T, Benlemlih M, Bennani B. Human papillomavirus infection and fertility alteration: a systematic review. PLoS One. 2015;10(5):e0126936. doi:10.1371/journal.pone.0126936