บทบาทของการใช้เทคนิคไอโซโทปแบบเสถียรเพื่องานด้านโภชนาการ

Alongkote Singhato; Narisa Rueangsri

doi:10.33165/rmj.2023.46.1.259923

Authors

Alongkote Singhato Nutrition and Dietetics Division, Faculty of Allied Health Sciences, Burapha University, Chon Buri, Thailand
Narisa Rueangsri Nutrition and Dietetics Division, Faculty of Allied Health Sciences, Burapha University, Chon Buri, Thailand

DOI:

https://doi.org/10.33165/rmj.2023.46.1.259923

Keywords:

Nutritional assessment, Stable isotope, Nutrition, Dietetics

Abstract

The stable isotope technique is one of the medical investigation that aims for differential diagnosis, as well as to monitor a patient’s condition using the radioactive substance, Nowadays, nutritional studies are using the stable isotope technique to explore the mechanism and the risk of malnutrition due to nutrient deficiency in several target groups. Thailand has had an announcement of the Royal Decree on Dietetics to be the standard for the art of healing in 2020. Therefore, registered dietitians are needed to improve themselves, especially in deep nutritional research to promote their professional impact and to support medical treatment. This review article aimed to present the basic principles of stable isotope in nutritional research. In addition, authors demonstrated published scientific evidence which applied nutritional research using stable isotopes in nutritional studies to investigate the absorption and bioavailability of nutrients such as iron and zinc and predicting the risk of malnutrition. Lastly, this article aimed to support the registered dietitian and other professionals in health care to generate research idea using stable isotopes in several nutrients and target groups.

References

National Research Council (US) and Institute of Medicine (US) Committee on State of the Science of Nuclear Medicine. Advancing Nuclear Medicine Through Innovation. National Academies Press (US); 2007:3.

Wang Y, Chen D, Augusto RDS, et al. Production review of accelerator-based medical isotopes. Molecules. 2022;27(16):5294. doi:10.3390/molecules27165294

Davies PSW. Stable isotopes: their use and safety in human nutrition studies. Eur J Clin Nutr. 2020;74(3):362-365. doi:10.1038/s41430-020-0580-0

Bruntz RC, Lane AN, Higashi RM, Fan TW. Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM). J Biol Chem. 2017;292(28):11601-11609. doi:10.1074/jbc.R117.776054

Karlstaedt A. Stable isotopes for tracing cardiac metabolism in diseases. Front Cardiovasc Med. 2021;8:734364. doi:10.3389/fcvm.2021.734364

Owino VO, Slater C, Loechl CU. Using stable isotope techniques in nutrition assessments and tracking of global targets post-2015. Proc Nutr Soc. 2017;76(4):495-503. doi:10.1017/S0029665117000295

Department of Health Service Support, Ministry of Public Health. Royal Decree of Registered Dietitian, B.E. 2563. June 23, 2020. Accessed January 18, 2023. http://www.ratchakitcha.soc.go.th/DATA/PDF/2563/A/046/T_0040.PDF

Abrha MW, Seid O, Gebremariam K, Kahsay A, Weldearegay HG. Nutritional status significantly affects hospital length of stay among surgical patients in public hospitals of Northern Ethiopia: single cohort study. BMC Res Notes. 2019;12:416. doi:10.1186/s13104-019-4451-5

Rueangsri N, Booranasuksakul U, Singhato A. Acceptance and satisfaction on Thai ethnic foods using the protein-free starchy products. Curr Res Nutr Food Sci. 2018;6(3):845-851. doi:10.12944/CRNFSJ.6.3.27

Singhato A, Booranasuksakul U, Khongkhon S, Rueangsri N. Acceptability of a high protein snack using artificial sweeteners for people living with HIV with oral problems. Curr Res Nutr Food Sci. 2018;6(3):711-719. doi:10.12944/CRNFSJ.6.3.13

Phillips GO, Pedraza JM. The International Atomic Energy Agency (IAEA) programme in radiation and tissue banking: past, present and future. Cell Tissue Bank. 2003;4(2-4):69-76. doi:10.1023/B:CATB.0000007021.81293.e4

Mew NA, Yudkoff M, Tuchman M. Stable isotopes in the diagnosis and treatment of inherited hyperammonemia. J Pediatr Biochem. 2014;4(1):57-63. doi:10.3233/JPB-140106

Boulyga SF. Calcium isotope analysis by mass spectrometry. Mass Spectrom Rev. 2010;29(5):685-716. doi:10.1002/mas.20244

Zheng J, Cao L, Tagami K, Uchida S. Triple-quadrupole inductively coupled plasma-mass spectrometry with a high-efficiency sample introduction system for ultratrace determination of 135Cs and 137Cs in environmental samples at femtogram levels. Anal Chem. 2016;88(17):8772-8779. doi:10.1021/acs.analchem.6b02150

Sugiyama N. Application note, 5991-0259EN: the accurate measurement of selenium in twelve diverse reference materials using on-line isotope dilution with the 8800 Triple Quadrupole ICP-MS in MS/MS mode. Agilent Technologies. April 1, 2012. Accessed January 18, 2023. https://www.agilent.com/cs/library/applications/5991-0259EN_AppNote_8800_Se.pdf

Abrams SA. Using stable isotopes to assess mineral absorption and utilization by children. Am J Clin Nutr. 1999;70:955-964. doi:10.1093/ajcn/70.6.955

Abrams SA. Assessing mineral metabolism in children using stable isotopes. Pediatr Blood Cancer. 2008;50(1):438-441. doi:10.1002/pbc.21417

Singhato A, Khongkhon S, Rueangsri N, Booranasuksakul U. Effectiveness of medical nutrition therapy to improve dietary habits for promoting bone health in people living with chronic HIV. Ann Nutr Metab. 2020;76(5):313-321. doi:10.1159/000510367

Floyd ZE, Ribnicky DM, Raskin I, Hsia DS, Rood JC, Gurley BJ. Designing a clinical study with dietary supplements: it's all in the details. Front Nutr. 2022;8:779486. doi:10.3389/fnut.2021.779486

Haron H, Shahar S, O’Brien KO, Ismail A, Kamaruddin N, Rahman SA. Absorption of calcium from milk and tempeh consumed by postmenopausal Malay women using the dual stable isotope technique. Int J Food Sci Nutr. 2010;61(2):125-137. doi:10.3109/09637480903348080

Sirichakwal PP, Kamchansuppasin A, Akoh CC, Kriengsinyos W, Charoenkiatkul S, O'Brien KO. Vitamin D status is positively associated with calcium absorption among postmenopausal Thai women with low calcium intakes. J Nutr. 2015;145(5):990-995. doi:10.3945/jn.114.207290

Suchdev PS, Namaste SM, Aaron GJ, Raiten DJ, et al. Overview of the biomarkers reflecting inflammation and nutritional determinants of anemia (BRINDA) project. Adv Nutr. 2016;7(2):349-356. doi:10.3945/an.115.010215

Lynch SR, Stoltzfus RJ. Iron and ascorbic acid: proposed fortification levels and recommended iron compounds. J Nutr. 2003;133(9):2978S-29784S. doi:10.1093/jn/133.9.2978S

Davidsson L, Tanumihardjo SA. Bioavailability. In: Caballero B, Allen LH, Prentice A, eds. Encyclopedia of Human Nutrition. 3rd ed. Academic Press; 2013:149-155.

Diaz M, Rosado JL, Allen LH, Abrams S, Garcia OP. The efficacy of a local ascorbic acid-rich food in improving iron absorption from Mexican diets: a field study using stable isotopes. Am J Clin Nutr. 2003;78(3):436-440. doi:10.1093/ajcn/78.3.436

Meija J, Coplen TB, Berglund M, et al. Isotopic compositions of the elements 2013 (IUPAC technical report). Pure Appl Chem. 2016;88(3):293-306. doi:10.1515/pac-2015-0503

Walczyk T, Tuntipopipat S, Zeder C, Sirichakwal P, Wasantwisut E, Hurrell RF. Iron absorption by human subjects from different iron fortification compounds added to Thai fish sauce. Eur J Clin Nutr. 2005;59(5):668-674. doi:10.1038/sj.ejcn.1602125

Fidler MC, Davidsson L, Zeder C, Walczyk T, Marti I, Hurrell RF. Effect of ascorbic acid and particle size on iron absorption from ferric pyrophosphate in adultwomen. Int J Vitam Nutr Res. 2004;74(4):294-300. doi:10.1024/0300-9831.74.4.294

Rosado JL, Hambidge KM, Miller LV, et al. The quantity of zinc absorbed from wheat in adult women is enhanced by biofortification. J Nutr. 2009;139(10):1920-1925. doi:10.3945/jn.109.107755

Agne-Djigo A, Idohou-Dossou N, Kwadjode KM, Tanumihardjo SA, Wade S. High prevalence of vitamin a deficiency is detected by the modified relative dose-response test in six-month-old Senegalese breast-fed infants. J Nutr. 2012;142(11):1991-1996. doi:10.3945/jn.112.166454

Tanumihardjo SA. Vitamin A fortification efforts require accurate monitoring of population vitamin a status to prevent excessive intakes. Procedia Chem. 2015;14:398-407. doi:10.1016/j.proche.2015.03.054

Fabbriciani G, De Socio GV, Massarotti M. Antiretroviral therapy and adverse skeletal effects. Mayo Clin Proc. 2011;86(9):916-917. doi:10.4065/mcp.2011.0341

International Atomic Energy Agency. IAEA Factsheet: How an Isotope Technique Helps Determine Protein Quality. IAEA Office of Public Information and Communication; 2020:1-4. Accessed January 18, 2023. https://www.iaea.org/sites/default/files/20/04/how-an-isotope-technique-helps-determine-protein-quality.pdf

Devi S, Varkey A, Sheshshayee MS, Preston T, Kurpad AV. Measurement of protein digestibility in humans by a dual-tracer method. Am J Clin Nutr. 2018;107(6):984-991. doi:10.1093/ajcn/nqy062